ArticleCritical care (London, England)2010
Association between regulatory T cell activity and sepsis and outcome of severely burned patients: a prospective, observational study.
Article in Critical care (London, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.
- Potential Targets to Mitigate Trauma- or Sepsis-Induced Immune Suppression.Frontiers in immunology · 2021Pooled it
- Early application of continuous high-volume haemofiltration can reduce sepsis and improve the prognosis of patients with severe burns.Critical care (London, England) · 2018Trial
- An mPFC-DMV cortical-autonomic-immune axis governs stress-induced immune dysregulation in sepsis.Molecular psychiatry · 2026Article
- Endocrine disruptions in thermal injuries: exploring immune system interactions.Physiological reviews · 2026Review
- Dynamic biomarker profiling and phenotyping in burn sepsis: a retrospective cohort study using growth mixture modeling.Frontiers in cellular and infection microbiology · 2026Article
- NuclearJournal of clinical & cellular immunology · 2025Article
- Dynamic functional assessment of T cells reveals an early suppression correlating with adverse outcome in polytraumatized patients.Frontiers in immunology · 2025Article
- The homeostasis and heterogeneity of regulatory T cells in sepsis.Burns & trauma · 2025Article
- Inhibition of USP11 attenuates sepsis-associated acute kidney injury by downregulating TGFBR2/Smad3 signaling.Frontiers in molecular biosciences · 2025Article
- CTLA-4 Checkpoint Inhibition Improves Sepsis Survival in Alcohol-Exposed Mice.ImmunoHorizons · 2024Article
- The Predictive Value of Absolute Lymphocyte Count and T Cell Subpopulations for Sepsis Prognosis.Infection and drug resistance · 2024Article
- Molecular mechanisms of Sepsis attacking the immune system and solid organs.Frontiers in medicine · 2024Review
- Th17/Treg balance: the bloom and wane in the pathophysiology of sepsis.Frontiers in immunology · 2024Review
- Prospective flow cytometry analysis of leucocyte subsets in critically ill patients who develop sepsis: a pilot study.Infection · 2023Article
- Auricular vagus nerve stimulation: a new option to treat inflammation in COVID-19?Revista da Associacao Medica Brasileira (1992) · 2023Article
- Advances in the Study of Immunosuppressive Mechanisms in Sepsis.Journal of inflammation research · 2023Review
- Expert consensus on the monitoring and treatment of sepsis-induced immunosuppression.Military Medical Research · 2022Article
- Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options.Military Medical Research · 2022Review
- The End of "One Size Fits All" Sepsis Therapies: Toward an Individualized Approach.Biomedicines · 2022Review
- Modern Aspects of Burn Injury Immunopathogenesis and Prognostic Immunobiochemical Markers (Mini-Review).Biotech (Basel (Switzerland)) · 2022Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionTo investigate the significance of changes in regulatory T cells (Tregs) activity and its relationship with sepsis, as well as outcome of patients with major burns.
methodsThe periphery blood samples of 106 patients were collected on post-burn days 1, 3, 7, 14, and 21. Tregs were isolated and their phenotypes (cytotoxic T-lymphocyte-associated antigen 4 and forkhead/winged helix transcription factor p3) were analyzed by flow cytometry, and the contents of cytokines (interleukin-10 and transforming growth factor-beta1) released into supernatants by Tregs were also determined by enzyme-linked immunosorbent assay kits. Gene expressions of cytokines were assessed by real-time quantitative polymerase chain reaction.
resultsExpressions of Tregs phenotypes and gene/protein expression of cytokines were all elevated after burn, and there were obvious differences among patients with various burn sizes. They were also higher in septic patients than those without sepsis. Among septic patients, the expressions of Tregs phenotypes and the levels of cytokines were markedly lower in the survival group than those in patients with fatal outcome.
conclusionsSevere burn injury per se could lead to the changes in Tregs activities. Elevated levels of cytokines produced by Tregs and activation markers on Tregs surface might play an important role in the pathogenesis of sepsis and mortality in burned patients.
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