ArticleReproductive biology and endocrinology : RB&E2010
Gene expression profile of androgen modulated genes in the murine fetal developing lung.
Article in Reproductive biology and endocrinology : RB&E, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 48 citations in OpenAlex.
- A Retrospective Study on the Risk of Respiratory Distress Syndrome in Singleton Pregnancies with Preterm Premature Rupture of Membranes between 24+0 and 36+6 Weeks, Using Regression Analysis for Various Factors.BioMed research international · 2018Trial
- Restricted mating windows and thrombospondin 2 gene deletion improve the precision of parturition timing in mice†.Biology of reproduction · 2025Article
- Global, regional and national trends in the burden of persistent pulmonary hypertension of the newborn and essentials of its management from 1993 to 2023: a scoping review.Frontiers in pediatrics · 2025Review
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- Global, Regional and National Trends in the Burden of Neonatal Respiratory Failure and essentials of its diagnosis and management from 1992 to 2022: a scoping review.European journal of pediatrics · 2024Article
- The expression of the surfactant proteins SP-A and SP-B during postnatal alveolarization of the rat lung.PloS one · 2024Article
- Growth and differentiation factor 15 (GDF15) levels predict adverse respiratory outcomes in premature neonates.Pediatric pulmonology · 2023Article
- Y It Matters-Sex Differences in Fetal Lung Development.Biomolecules · 2022Review
- Review
- MicroRNA Signatures Associated with Bronchopulmonary Dysplasia Severity in Tracheal Aspirates of Preterm Infants.Biomedicines · 2021Article
- May patients receiving 5-alpha-reductase inhibitors be in higher risk of COVID-19 complications?Medical hypotheses · 2020Article
- Effects of 5-alpha reductase inhibitors on lung function: A reason for discontinuation during COVID-19 pandemic?Dermatologic therapy · 2020Article
- Role of Growth Differentiation Factor 15 in Lung Disease and Senescence: Potential Role Across the Lifespan.Frontiers in medicine · 2020Review
- Risk factors for respiratory distress syndrome in full-term neonates.Yeungnam University journal of medicine · 2018Article
- Expression profile of androgen-modulated microRNAs in the fetal murine lung.Biology of sex differences · 2016Article
- Single-cell analysis reveals differential regulation of the alveolar macrophage actin cytoskeleton by surfactant proteins A1 and A2: implications of sex and aging.Biology of sex differences · 2016Article
- Article
- High-risk Factors of Respiratory Distress Syndrome in Term Neonates: A Retrospective Case-control Study.Balkan medical journal · 2014Article
- Identification of most stable endogenous control genes for microRNA quantification in the developing mouse lung.PloS one · 2014Article
- miRNA regulated pathways in late stage murine lung development.BMC developmental biology · 2013Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundAccumulating evidences suggest that sex affects lung development. Indeed, a higher incidence of respiratory distress syndrome is observed in male compared to female preterm neonates at comparable developmental stage and experimental studies demonstrated an androgen-related delay in male lung maturation. However, the precise mechanisms underlying these deleterious effects of androgens in lung maturation are only partially understood.
methodsTo build up a better understanding of the effect of androgens on lung development, we analyzed by microarrays the expression of genes showing a sexual difference and those modulated by androgens. Lungs of murine fetuses resulting from a timely mating window of 1 hour were studied at gestational day 17 (GD17) and GD18, corresponding to the period of surge of surfactant production. Using injections of the antiandrogen flutamide to pregnant mice, we hunted for genes in fetal lungs which are transcriptionally modulated by androgens.
resultsResults revealed that 1844 genes were expressed with a sexual difference at GD17 and 833 at GD18. Many genes were significantly modulated by flutamide: 1597 at GD17 and 1775 at GD18. Datasets were analyzed by using in silico tools for reconstruction of cellular pathways. Between GD17 and GD18, male lungs showed an intensive transcriptional activity of proliferative pathways along with the onset of lung differentiation. Among the genes showing a sex difference or an antiandrogen modulation of their expression, we specifically identified androgen receptor interacting genes, surfactant related genes in particularly those involved in the pathway leading to phospholipid synthesis, and several genes of lung development regulator pathways. Among these latter, some genes related to Shh, FGF, TGF-beta, BMP, and Wnt signaling are modulated by sex and/or antiandrogen treatment.
conclusionOur results show clearly that there is a real delay in lung maturation between male and female in this period, the latter pursuing already lung maturation while the proper is not yet fully engaged in the differentiation processes at GD17. In addition, this study provides a list of genes which are under the control of androgens within the lung at the moment of surge of surfactant production in murine fetal lung.
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