ArticleJournal of the American Chemical Society2010
Analysis of p300/CBP histone acetyltransferase regulation using circular permutation and semisynthesis.
Article in Journal of the American Chemical Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 20 citations in OpenAlex.
- HAT1 as a Lactyltransferase to Promote DNA Repair Through RPA1 Lactylation in Glioblastoma.International journal of biological sciences · 2026Article
- Advances in the chemical synthesis of human proteoforms.Science China. Life sciences · 2025Review
- Interrogating epigenetic mechanisms with chemically customized chromatin.Nature reviews. Genetics · 2024Review
- Efficacy of the monocarbonyl curcumin analog C66 in the reduction of diabetes-associated cardiovascular and kidney complications.Molecular medicine (Cambridge, Mass.) · 2022Review
- 2-month ketogenic diet preferentially alters skeletal muscle and augments cognitive function in middle aged female mice.Aging cell · 2022Article
- Chemoenzymatic Semisynthesis of Proteins.Chemical reviews · 2020Review
- USP12 translocation maintains interferon antiviral efficacy by inhibiting CBP acetyltransferase activity.PLoS pathogens · 2020Article
- Hydrazide Mimics for Protein Lysine Acylation To Assess Nucleosome Dynamics and Deubiquitinase Action.Journal of the American Chemical Society · 2018Article
- Lysine Acetylation Goes Global: From Epigenetics to Metabolism and Therapeutics.Chemical reviews · 2018Review
- Platelet activating factor-induced expression of p21 is correlated with histone acetylation.Scientific reports · 2017Article
- Synthetic approaches to protein phosphorylation.Current opinion in chemical biology · 2015Review
- Protein lysine acetylation by p300/CBP.Chemical reviews · 2015Review
- Metabolic regulation of histone post-translational modifications.ACS chemical biology · 2015Review
- Novel curcumin analog C66 prevents diabetic nephropathy via JNK pathway with the involvement of p300/CBP-mediated histone acetylation.Biochimica et biophysica acta · 2015Article
- Regulation of S-adenosylhomocysteine hydrolase by lysine acetylation.The Journal of biological chemistry · 2014Article
- Catalytic mechanism of histone acetyltransferase p300: from the proton transfer to acetylation reaction.The journal of physical chemistry. B · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The histone acetyltransferase (HAT) p300/CBP has been shown to undergo autoacetylation on lysines in an apparent regulatory loop that stimulates HAT activity. Here we have developed a strategy to introduce acetyl-Lys at up to six known modification sites in p300/CBP HAT using a combination of circular permutation and expressed protein ligation. We show that these semisynthetic, circularly permuted acetylated proteins retain high affinity for an acetyl-CoA substrate analogue and that HAT activity correlates positively with degree of acetylation. This study provides novel evidence for control of p300/CBP HAT activity by site-specific autoacetylation and outlines a potentially general strategy for using expressed protein ligation and circular permutation to chemically interrogate internal regions of proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.