ArticleBirth defects research. Part A, Clinical and molecular teratology2010
Periconceptional nutrient intakes and risks of conotruncal heart defects.
Article in Birth defects research. Part A, Clinical and molecular teratology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Effect of maternal dietary niacin intake on congenital anomalies: a systematic review and meta-analysis.European journal of nutrition · 2022Pooled it
- Evaluation of the association between maternal folic acid supplementation and the risk of congenital heart disease: a systematic review and meta-analysis.Nutrition journal · 2022Pooled it
- The roles ofBioscience reports · 2018Pooled it
- Maternal Anaemia and Congenital Heart Disease in Offspring: A Case-Control Study Using Linked Electronic Health Records in the United Kingdom.BJOG : an international journal of obstetrics and gynaecology · 2025Article
- Association between maternal folic acid and/or multivitamin supplementation time and fetal congenital heart disease: based on the China birth cohort study.International journal of medical sciences · 2025Article
- Scientific opinion on the tolerable upper intake level for preformed vitamin A and β-carotene.EFSA journal. European Food Safety Authority · 2024Article
- Article
- Response to the letter to editor: Can niacin supplementation prevent congenital malformations associated with maternal use of proton pump inhibitors?European journal of nutrition · 2023Article
- Dietary Intake of Micronutrients and Essential Fatty Acids among Overweight or Obese Pregnant Women during Early Pregnancy.Journal of pediatrics, perinatology and child health · 2023Article
- Evidence based recommendations for an optimal prenatal supplement for women in the US: vitamins and related nutrients.Maternal health, neonatology and perinatology · 2022Review
- Association of maternal dietary habits and ADIPOQ gene polymorphisms with the risk of congenital heart defects in offspring: a hospital-based case-control study.European journal of clinical nutrition · 2022Article
- The association between folic acid supplementation and congenital heart defects: Systematic review and meta-analysis.SAGE open medicine · 2022Article
- Associations of maternal dietary patterns during pregnancy and fetal intrauterine development.Frontiers in nutrition · 2022Article
- Association between maternal iron supplementation and newborn birth weight: a quantile regression analysis.Italian journal of pediatrics · 2021Article
- Association and interaction effect of UCP2 gene polymorphisms and dietary factors with congenital heart diseases in Chinese Han population.Scientific reports · 2021Article
- Association of Maternal Dietary Habits andFrontiers in pediatrics · 2021Article
- Environmental Risk Factors for Congenital Heart Disease.Cold Spring Harbor perspectives in biology · 2020Review
- Risk factors for congenital heart disease: The Baby Hearts Study, a population-based case-control study.PloS one · 2020Article
- Association Between Maternal Folic Acid Supplementation and Congenital Heart Defects in Offspring in Birth Cohorts From Denmark and Norway.Journal of the American Heart Association · 2019Article
- Macronutrient and Micronutrient Intake during Pregnancy: An Overview of Recent Evidence.Nutrients · 2019Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundFew inquiries into periconceptional nutrition, other than folate, and risk of heart defects exist. We investigated the observed association between conotruncal heart defects and periconceptional vitamin use, as well as potential associations with other dietary nutrients.
methodsData derived from a population-based, case-control study of fetuses and liveborn infants among California births between July 1999 and June 2004; 76% of eligible case mothers and 77% of eligible control mothers were interviewed. Cases included 140 with d-transposition of great arteries (dTGA), and 163 with tetralogy of Fallot (TOF). Total number of controls was 698. Use of vitamins was elicited by questionnaire for the periconceptional period. Dietary nutrient intake was elicited by a well-known food frequency questionnaire.
resultsThe odds ratio for dTGA associated with supplemental vitamin use was 1.0 (95% confidence interval [CI], 0.7-1.5) and for TOF was 0.9 (95% CI, 0.6-1.3). We observed increased risks associated with lower dietary intakes of linoleic acid, total carbohydrate, and fructose for dTGA, whereas decreased risks were observed for lower intakes of total protein and methionine for TOF. Lower dietary intake of several micronutrients-namely folate, niacin, riboflavin, and vitamins B(12), A, and E, even after simultaneous adjustment for other studied nutrients-was associated with increased risk of dTGA but not TOF. These associations were observed among women who did not use vitamin supplements periconceptionally. Analytic consideration of several potential confounders did not reveal alternative interpretations of the results.
conclusionEvidence continues to accumulate to show that nutrients, particularly folate, influence risks of structural birth defects. Our results extend observations that other nutrients may also be important in heart development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.