Evidence map›Paper›PMID 20063147›Full record

SynthesisDiabetologia2010

Birthweight and the risk of childhood-onset type 1 diabetes: a meta-analysis of observational studies using individual patient data.

C R Cardwell, L C Stene, G Joner, E A Davis, O Cinek, J Rosenbauer, J Ludvigsson, C Castell, J Svensson, M J Goldacre and 17 more

Abstract readMeta-AnalysisMulticenter Study
PubMed Publisher
In one paragraph

Synthesis in Diabetologia, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  4. Overweight and obesity in youth with type 1 diabetes.Annual review of nursing research · 2013
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

C R CardwellCentre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Grosvenor Road, Belfast BT12 6BJ, UK, c.cardwell@qub.ac.uk
L C Stene
G Joner
E A Davis
O Cinek
J Rosenbauer
J Ludvigsson
C Castell
J Svensson
M J Goldacre
T Waldhoer
J Polanska
S G A Gimeno
L-M Chuang
R C Parslow
E J K Wadsworth
A Chetwynd
P Pozzilli
G Brigis
B Urbonaite
S Sipetić
E Schober
C Ionescu-Tirgoviste
C E de Beaufort
D Stoyanov
K Buschard
C C Patterson

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aims/hypothesisWe investigated whether children who are heavier at birth have an increased risk of type 1 diabetes.

methodsRelevant studies published before February 2009 were identified from literature searches using MEDLINE, Web of Science and EMBASE. Authors of all studies containing relevant data were contacted and asked to provide individual patient data or conduct pre-specified analyses. Risk estimates of type 1 diabetes by category of birthweight were calculated for each study, before and after adjustment for potential confounders.Meta-analysis techniques were then used to derive combined ORs and investigate heterogeneity between studies.

resultsData were available for 29 predominantly European studies (five cohort, 24 case-control studies), including 12,807 cases of type 1 diabetes. Overall, studies consistently demonstrated that children with birthweight from 3.5 to 4 kg had an increased risk of diabetes of 6% (OR 1.06 [95% CI 1.01-1.11]; p=0.02) and children with birthweight over 4 kg had an increased risk of 10% (OR 1.10 [95% CI 1.04-1.19]; p=0.003), compared with children weighing 3.0 to 3.5 kg at birth. This corresponded to a linear increase in diabetes risk of 3% per 500 g increase in birthweight (OR 1.03 [95% CI 1.00-1.06]; p=0.03). Adjustments for potential confounders such as gestational age, maternal age, birth order, Caesarean section, breastfeeding and maternal diabetes had little effect on these findings. CONCLUSIONS/

interpretationChildren who are heavier at birth have a significant and consistent, but relatively small increase in risk of type 1 diabetes.

Indexed as

Birth WeightAdolescentAge of OnsetBirth OrderChildChild, PreschoolDiabetes Mellitus, Type 1FemaleGestational AgeHumansInfantInfant, NewbornMaternal AgePregnancyRisk Factors

Identifiers

PMID20063147

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.