ArticleCellular and molecular life sciences : CMLS2010
Identification and characterization of new functional truncated variants of somatostatin receptor subtype 5 in rodents.
Article in Cellular and molecular life sciences : CMLS, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Clinical and prognostic significance of granulation patterns in somatotroph adenomas/tumors of the pituitary: a meta-analysis.Pituitary · 2023Pooled it
- Trial
- Cortistatin deficiency reveals a dysfunctional brain endothelium with impaired gene pathways, exacerbated immune activation, and disrupted barrier integrity.Journal of neuroinflammation · 2023Article
- Selective somatostatin receptor 5 inhibition improves hepatic insulin sensitivity.Pharmacology research & perspectives · 2023Article
- Non-full-length Water-Soluble CXCR4iScience · 2020Article
- Characterization of agonist-dependent somatostatin receptor subtype 2 trafficking in neuroendocrine cells.Endocrine · 2020Article
- Central somatostatin signaling and regulation of food intake.Annals of the New York Academy of Sciences · 2019Review
- Clinical significance of filamin A in patients with acromegaly and its association with somatostatin and dopamine receptor profiles.Scientific reports · 2019Article
- Spotlight on telotristat ethyl for the treatment of carcinoid syndrome diarrhea: patient selection and reported outcomes.Cancer management and research · 2019Review
- International Union of Basic and Clinical Pharmacology. CV. Somatostatin Receptors: Structure, Function, Ligands, and New Nomenclature.Pharmacological reviews · 2018Review
- BNGR-A25L and -A27 are two functional G protein-coupled receptors for CAPA periviscerokinin neuropeptides in the silkwormThe Journal of biological chemistry · 2017Article
- Article
- Review
- Neuropeptides and Microglial Activation in Inflammation, Pain, and Neurodegenerative Diseases.Mediators of inflammation · 2017Review
- Activation of Brain Somatostatin Signaling Suppresses CRF Receptor-Mediated Stress Response.Frontiers in neuroscience · 2017Review
- Obesity- and gender-dependent role of endogenous somatostatin and cortistatin in the regulation of endocrine and metabolic homeostasis in mice.Scientific reports · 2016Article
- Lack of cortistatin or somatostatin differentially influences DMBA-induced mammary gland tumorigenesis in mice in an obesity-dependent mode.Breast cancer research : BCR · 2016Article
- The role of brain somatostatin receptor 2 in the regulation of feeding and drinking behavior.Hormones and behavior · 2015Review
- Truncated somatostatin receptor variant sst5TMD4 confers aggressive features (proliferation, invasion and reduced octreotide response) to somatotropinomas.Cancer letters · 2015Article
- Obesity alters gene expression for GH/IGF-I axis in mouse mammary fat pads: differential role of cortistatin and somatostatin.PloS one · 2015Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Somatostatin and cortistatin exert multiple biological actions through five receptors (sst1-5); however, not all their effects can be explained by activation of sst1-5. Indeed, we recently identified novel truncated but functional human sst5-variants, present in normal and tumoral tissues. In this study, we identified and characterized three novel truncated sst5 variants in mice and one in rats displaying different numbers of transmembrane-domains [TMD; sst5TMD4, sst5TMD2, sst5TMD1 (mouse-variants) and sst5TMD1 (rat-variant)]. These sst5 variants: (1) are functional to mediate ligand-selective-induced variations in [Ca(2+)]i and cAMP despite being truncated; (2) display preferential intracellular distribution; (3) mostly share full-length sst5 tissue distribution, but exhibit unique differences; (4) are differentially regulated by changes in hormonal/metabolic environment in a tissue- (e.g., central vs. systemic) and ligand-dependent manner. Altogether, our results demonstrate the existence of new truncated sst5-variants with unique ligand-selective signaling properties, which could contribute to further understanding the complex, distinct pathophysiological roles of somatostatin and cortistatin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.