ArticleJournal of Korean Neurosurgical Society2009
Clinical results of cyberknife(r) radiosurgery for spinal metastases.
Article in Journal of Korean Neurosurgical Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- A Systematic Review of Metastatic Hepatocellular Carcinoma to the Spine.World neurosurgery · 2016Pooled it
- A glimpse into the CyberKnife robotic radiosurgery system: technical specifications and developments during thirty years.Frontiers in oncology · 2026Review
- Nucleus Accumbens: A Therapeutic Target for Radiomodulation for the Treatment of Alcohol Use Disorder.Cureus · 2025Review
- The impact of radiosensitivity on clinical outcomes of spinal metastases treated with stereotactic body radiotherapy.Cancer medicine · 2023Article
- Stereotactic body radiotherapy for spinal metastases: a review.Medical oncology (Northwood, London, England) · 2022Review
- Image-Guided Robotic Radiosurgery for the Treatment of Same Site Spinal Metastasis Recurrences.Frontiers in oncology · 2021Article
- Dose fall-off during the treatment of thoracic spine metastasis with CyberKnife stereotactic body radiation therapy (SBRT).Bosnian journal of basic medical sciences · 2020Article
- Developments in Stereotactic Body Radiotherapy.Cancers · 2018Review
- [Intramedullary metastasis of lung adenocarcinoma: about a case].The Pan African medical journal · 2015Article
- Successful treatment of infantile fibrosarcoma spinal metastasis by chemotherapy and stereotactic hypofractionated radiotherapy.Journal of Korean Neurosurgical Society · 2013Article
- Unexpected seizure attack in a patient with spinal metastasis diagnosed as posterior reversible encephalopathy syndrome.Journal of Korean Neurosurgical Society · 2011Article
- Stereotactic radiosurgery for spinal metastases: a literature review.Einstein (Sao Paulo, Brazil)Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePrimary treatment of spinal metastasis has been external beam radiotherapy. Recent advance of technology enables radiosurgery to be extended to extracranial lesions. The purpose of this study was to determine the clinical effectiveness and safety of stereotactic radiosurgery using Cyberknife in spinal metastasis.
methodsFrom June, 2002 to December, 2007, 129 patients with 167 spinal metastases were treated with Cyberknife. Most of the patients (94%) presented with pain and nine patients suffered from motor deficits. Twelve patients were asymptomatic. Fifty-three patients (32%) had previous radiation therapy. Using Cyberknife, 16-39 Gy in 1-5 fractions were delivered to spinal metastatic lesions. Radiation dose was not different regarding the tumor pathology or tumor volume.
resultsAfter six months follow-up, patient evaluation was possible in 108 lesions. Among them, significant pain relief was seen in 98 lesions (91%). Radiological data were obtained in 83 lesions. The mass size was decreased or stable in 75 lesions and increased in eight lesions. Radiological control failure cases were hepatocellular carcinoma (5 cases), lung cancer (1 case), breast cancer (1 case) and renal cell carcinoma (1 case). Treatment-related radiation injury was not detected.
conclusionCyberknife radiosurgery is clinically effective and safe for spinal metastases. It is true even in previously irradiated patients. Compared to conventional radiation therapy, Cyberknife shows higher pain control rate and its treatment process is more convenient for patients. Thus, it can be regarded as a primary treatment modality for spinal metastases.
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