ArticleMolecular vision2010
An association study of SERPING1 gene and age-related macular degeneration in a Han Chinese population.
Article in Molecular vision, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Relationship between SERPING1 rs2511989 polymorphism and age-related macular degeneration risk: a meta-analysis.Molecular vision · 2014Pooled it
- Gene variants of coagulation related proteins that interact with SARS-CoV-2.PLoS computational biology · 2021Article
- Comparison of machine learning tools for the prediction of AMD based on genetic, age, and diabetes-related variables in the Chinese population.Regenerative therapy · 2020Article
- Genetic variants influencing lipid levels and risk of dyslipidemia in Chinese population.Journal of genetics · 2017Article
- Genetics of Hereditary Angioedema Revisited.Clinical reviews in allergy & immunology · 2016Review
- Association of Htra1 gene polymorphisms with the risk of developing AMD in Iranian population.Reports of biochemistry & molecular biology · 2015Article
- Ethnic differences in the association of SERPING1 with age-related macular degeneration and polypoidal choroidal vasculopathy.Scientific reports · 2015Article
- Association between SERPING1 rs2511989 polymorphism and age-related macular degeneration: Meta-analysis.International journal of ophthalmology · 2015Article
- Genetic insights into age-related macular degeneration: controversies addressing risk, causality, and therapeutics.Molecular aspects of medicine · 2012Review
- Preservation of cone photoreceptors after a rapid yet transient degeneration and remodeling in cone-only Nrl-/- mouse retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Association between the SERPING1 gene and age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese.PloS one · 2011Article
Corrections and comments
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Authors and funding
16 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSingle nucleotide polymorphisms (SNPs) in the complement component 1 inhibitor (SERPING1) gene have been shown to be significantly associated with age-related macular degeneration (AMD) in Caucasian populations. A replication study of an association between these SNPs and AMD in a Chinese population is reported in this study.
methodsSix SNPs, including rs2511990, rs1005510, rs11546660, rs2511989, rs2511988, and rs4926 in SERPING1 were genotyped in a Han Chinese subject group using the SNaPshot method of ABI. This subject group was composed of 194 patients with choroidal neovascularization (CNV or wet) AMD, 78 patients with soft drusen, and 285 matched controls. P values of the SNPs were calculated using an additive model. Haplotype frequencies between cases and controls were compared by chi2 analysis. The haplotype analysis was performed using Haploview 4.0.
resultsNone of the six SNPs showed significant association with AMD. None of the major haplotypes were observed to be significantly associated with AMD or choroidal neovascularization AMD (CNV) after a stringent Bonferroni correction.
conclusionsWe demonstrate that SNPs in SERPING1 are not significantly associated with AMD in the mainland Han Chinese population.
Indexed as
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20062564PMC2803124W2140858486What OpenQuestion holds
Registered trials
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