ArticleNature genetics2010
Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk.
Article in Nature genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers, 14 of them syntheses that pooled it.
What it found
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Who cites it
131 citing papers in PubMed, 14 syntheses or guidelines pooled it.
- Role of Polygenic Risk Score in Cancer Precision Medicine of Non-European Populations: A Systematic Review.Current oncology (Toronto, Ont.) · 2022Pooled it
- Common genetic polymorphisms contribute to the association between chronic lymphocytic leukaemia and non-melanoma skin cancer.International journal of epidemiology · 2021Pooled it
- Multiple myeloma and family history of lymphohaematopoietic cancers: Results from the International Multiple Myeloma Consortium.British journal of haematology · 2016Pooled it
- Genome-wide association study identifies multiple susceptibility loci for multiple myeloma.Nature communications · 2016Pooled it
- Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia.Nature communications · 2016Pooled it
- Association of Interferon Gamma +874T/A Polymorphism and Leukemia Risk: A Meta-Analysis.Medicine · 2016Pooled it
- Pooled it
- Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma.Nature genetics · 2014Pooled it
- MDM2 promotor polymorphism and disease characteristics in chronic lymphocytic leukemia: results of an individual patient data-based meta-analysis.Haematologica · 2014Pooled it
- Pooled it
- A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.Nature genetics · 2014Pooled it
- Pleiotropy of cancer susceptibility variants on the risk of non-Hodgkin lymphoma: the PAGE consortium.PloS one · 2014Pooled it
- Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.Nature genetics · 2013Pooled it
- Multiple loci are associated with white blood cell phenotypes.PLoS genetics · 2011Pooled it
- Search for an aetiological virus candidate in chronic lymphocytic leukaemia by extensive transcriptome analysis.British journal of haematology · 2012Trial
- Association between single nucleotide polymorphism-genotype and outcome of patients with chronic lymphocytic leukemia in a randomized chemotherapy trial.Haematologica · 2011Trial
- Regulatory factor X 7 limits Myc activity during B cell activation and suppresses Myc-dependent lymphomagenesis.Nature immunology · 2026Article
- Article
- In-silico identification of genetic variants associated with chronic lymphocytic leukemia for diagnostic and therapeutic applications.Scientific reports · 2026Article
- European-based polygenic risk score and genome-wide association study of B-cell non-Hodgkin lymphoma subtypes in Israeli Jews and Palestinian Arabs.British journal of haematology · 2025Article
71 more citing papers are in PubMed but not listed here.
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Authors and funding
35 authors.
Funding
Abstract
To identify new risk variants for chronic lymphocytic leukemia (CLL), we conducted a genome-wide association study of 299,983 tagging SNPs, with validation in four additional series totaling 2,503 cases and 5,789 controls. We identified four new risk loci for CLL at 2q37.3 (rs757978, FARP2; odds ratio (OR) = 1.39; P = 2.11 x 10(-9)), 8q24.21 (rs2456449; OR = 1.26; P = 7.84 x 10(-10)), 15q21.3 (rs7169431; OR = 1.36; P = 4.74 x 10(-7)) and 16q24.1 (rs305061; OR = 1.22; P = 3.60 x 10(-7)). We also found evidence for risk loci at 15q25.2 (rs783540, CPEB1; OR = 1.18; P = 3.67 x 10(-6)) and 18q21.1 (rs1036935; OR = 1.22; P = 2.28 x 10(-6)). These data provide further evidence for genetic susceptibility to this B-cell hematological malignancy.
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