ArticleNature genetics2010
Genetic variation in SCN10A influences cardiac conduction.
Article in Nature genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 155 papers, 12 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
155 citing papers in PubMed, 12 syntheses or guidelines pooled it, 281 citations in OpenAlex.
- Genetic insights into cardiac conduction disorders from genome-wide association studies.Human genomics · 2025Pooled it
- Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction.Nature communications · 2020Pooled it
- Pooled it
- Genome-wide association study of PR interval in Hispanics/Latinos identifies novel locus atHeart (British Cardiac Society) · 2018Pooled it
- Common and Rare Coding Genetic Variation Underlying the Electrocardiographic PR Interval.Circulation. Genomic and precision medicine · 2018Pooled it
- Fifteen Genetic Loci Associated With the Electrocardiographic P Wave.Circulation. Cardiovascular genetics · 2017Pooled it
- Fine-mapping, novel loci identification, and SNP association transferability in a genome-wide association study of QRS duration in African Americans.Human molecular genetics · 2016Pooled it
- Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval.The pharmacogenomics journal · 2014Pooled it
- Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.The American journal of clinical nutrition · 2013Pooled it
- Transethnic meta-analysis of genomewide association studies.Genetic epidemiology · 2011Pooled it
- Genome-wide association studies of the PR interval in African Americans.PLoS genetics · 2011Pooled it
- Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction.Nature genetics · 2010Pooled it
- Common and rare variants in SCN10A modulate the risk of atrial fibrillation.Circulation. Cardiovascular genetics · 2015Trial
- Genome-wide identification of expression quantitative trait loci (eQTLs) in human heart.PloS one · 2014Trial
- Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk.Circulation · 2013Trial
- Chasing the Wrong Door for 30 Years: Is Suzetrigine the Key to Selective Pain Relief?Medicina (Kaunas, Lithuania) · 2026Review
- The cardiac conduction system: development, function and therapeutic targets.Nature reviews. Cardiology · 2026Review
- MOG1medRxiv : the preprint server for health sciences · 2025Article
- Electrocardiogram characteristics and possible associated factors in healthy Japanese children: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.BMC pediatrics · 2025Article
- Sensory neuron sodium channels as pain targets; from cocaine to Journavx (VX-548, suzetrigine).The Journal of general physiology · 2025Review
95 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors at 6 institutions in 2 countries.
Funding
Abstract
To identify genetic factors influencing cardiac conduction, we carried out a genome-wide association study of electrocardiographic time intervals in 6,543 Indian Asians. We identified association of a nonsynonymous SNP, rs6795970, in SCN10A (P = 2.8 x 10(-15)) with PR interval, a marker of cardiac atrioventricular conduction. Replication testing among 6,243 Indian Asians and 5,370 Europeans confirmed that rs6795970 (G>A) is associated with prolonged cardiac conduction (longer P-wave duration, PR interval and QRS duration, P = 10(-5) to 10(-20)). SCN10A encodes Na(V)1.8, a sodium channel. We show that SCN10A is expressed in mouse and human heart tissue and that PR interval is shorter in Scn10a(-/-) mice than in wild-type mice. We also find that rs6795970 is associated with a higher risk of heart block (P < 0.05) and a lower risk of ventricular fibrillation (P = 0.01). Our findings provide new insight into the pathogenesis of cardiac conduction, heart block and ventricular fibrillation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.