ArticleNature structural & molecular biology2010
Allosteric regulation of Argonaute proteins by miRNAs.
Article in Nature structural & molecular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed.
- The ubiquitin-proteasome pathway mediates selective degradation of unloaded Argonaute proteins in C. elegans.Genetics · 2026Article
- Decoding Argonaute specificity: insights fromRNA (New York, N.Y.) · 2026Review
- Co-option of the piRNA pathway to regulate neural crest specification.Science advances · 2022Article
- Chilling Stress Triggers VvAgo1-Mediated miRNA-Like RNA Biogenesis inFrontiers in microbiology · 2020Article
- Temporospatial guidance of activity-dependent gene expression by microRNA: mechanisms and functional implications for neural plasticity.Nucleic acids research · 2019Review
- MicroRNAs recruit eIF4E2 to repress translation of target mRNAs.Protein & cell · 2017Article
- Aub and Ago3 Are Recruited to Nuage through Two Mechanisms to Form a Ping-Pong Complex Assembled by Krimper.Molecular cell · 2015Article
- The capacity of target silencing by Drosophila PIWI and piRNAs.RNA (New York, N.Y.) · 2014Article
- In vitro selection of shape-changing DNA nanostructures capable of binding-induced cargo release.ACS nano · 2013Article
- miRISC recruits decapping factors to miRNA targets to enhance their degradation.Nucleic acids research · 2013Article
- Argonaute protein as a linker to command center of physiological processes.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2013Article
- Molecular dissection of human Argonaute proteins by DNA shuffling.Nature structural & molecular biology · 2013Article
- Regulation of Argonaute slicer activity by guide RNA 3' end interactions with the N-terminal lobe.The Journal of biological chemistry · 2013Article
- Piwi induces piRNA-guided transcriptional silencing and establishment of a repressive chromatin state.Genes & development · 2013Article
- Regulation of miR106b cluster through the RB pathway: mechanism and functional targets.Cell cycle (Georgetown, Tex.) · 2013Article
- eIF4GI facilitates the MicroRNA-mediated gene silencing.PloS one · 2013Article
- The slicing activity of miRNA-specific Argonautes is essential for the miRNA pathway in C. elegans.Nucleic acids research · 2012Article
- The true core of RNA silencing revealed.Nature structural & molecular biology · 2012Article
- The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC.Nature structural & molecular biology · 2012Review
- MicroRNAs: molecular features and role in cancer.Frontiers in bioscience (Landmark edition) · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Small interfering RNAs (siRNAs) and microRNAs (miRNAs) bind to Argonaute (AGO) family proteins to form a related set of effector complexes that have diverse roles in post-transcriptional gene regulation throughout the eukaryotic lineage. Here sequence and structural analysis of the MID domain of the AGO proteins identified similarities with a family of allosterically regulated bacterial ligand-binding domains. We used in vitro and in vivo approaches to show that certain AGO proteins (those involved in translational repression) have conserved this functional allostery between two distinct sites, one involved in binding miRNA-target duplex and the other in binding the 5' cap feature (m(7)GpppG) of eukaryotic mRNAs. This allostery provides an explanation for how miRNA-bound effector complexes may avoid indiscriminate repressive action (mediated through binding interactions with the cap) before full target recognition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.