ArticleMenopause (New York, N.Y.)
ALOX12 gene is associated with the onset of natural menopause in white women.
Article in Menopause (New York, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Ovariectomy Via 12/15-lipoxygenase Augments Angiotensin II-Induced Hypertension and Its Pathogenesis in Female Mice.Hypertension (Dallas, Tex. : 1979) · 2023Article
- Biochemical and hydrogen-deuterium exchange studies of the single nucleotide polymorphism Y649C in human platelet 12-lipoxygenase linked to a bleeding disorder.Archives of biochemistry and biophysics · 2023Article
- Genetic Variants inFrontiers in oncology · 2021Article
- Mutation in ALOX12B likely cause of POI and also ichthyosis in a large Iranian pedigree.Molecular genetics and genomics : MGG · 2020Article
- Study on follicular fluid metabolomics components at different ages based on lipid metabolism.Reproductive biology and endocrinology : RB&E · 2020Article
- Effects of Early Intervention With Maternal Fecal Bacteria and Antibiotics on Liver Metabolome and Transcription in Neonatal Pigs.Frontiers in physiology · 2019Article
- Decreased ovarian reserve, dysregulation of mitochondrial biogenesis, and increased lipid peroxidation in female mouse offspring exposed to an obesogenic maternal diet.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- Associations between ALOX, COX, and CRP polymorphisms and breast cancer among Hispanic and non-Hispanic white women: The breast cancer health disparities study.Molecular carcinogenesis · 2015Article
- Evolutionary aspects of lipoxygenases and genetic diversity of human leukotriene signaling.Progress in lipid research · 2015Review
- Non-synonymous polymorphism (Gln261Arg) of 12-lipoxygenase in colorectal and thyroid cancers.Familial cancer · 2012Article
- A chromosome 19 locus positively influences the number of retrieved oocytes during stimulated cycles in Brazilian women.Journal of assisted reproduction and genetics · 2012Article
- Association of a functional polymorphism (Gln261Arg) in 12-lipoxygenase with breast cancer.Experimental and therapeutic medicine · 2011Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveNatural menopause is a key physiological event in a woman's life. Timing of menopause affects risk for many postmenopausal systemic disorders and may thus influence life expectancy. Age at natural menopause (ANM) is largely determined genetically, but a list of candidate genes is far from complete. This study investigated the ALOX12 gene for its possible association with ANM.
methodsSix single-nucleotide polymorphisms (SNPs) of the gene (rs9904779, rs2073438, rs11571340, rs434473, rs2307214, and rs312462) were genotyped in a random sample of 210 unrelated white women. The SNPs and common haplotypes were then analyzed for their association with ANM. Smoking, alcohol consumption, and duration of breast-feeding were used as covariates.
resultsTwo SNPs, rs9904779 and rs434473 (encodes a replacement of asparagine by serine in the protein), were significantly associated with ANM (P = 0.022 and 0.033, respectively). The minor alleles of both SNPs seem to promote about 1.3- to 1.5-year earlier menopause and confer a 1.6 to 1.8 times higher risk for early menopause. All SNPs indicated significant or nearly significant interactions with alcohol use and duration of breast-feeding. Five common haplotypes were also associated with ANM.
conclusionsThe ALOX12 gene seems to be associated with the timing of natural menopause in white women.
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