ArticleProceedings of the National Academy of Sciences of the United States of America1991
Drug-induced DNA repair: X-ray structure of a DNA-ditercalinium complex.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 74 citations in OpenAlex.
- Structural basis for asymmetric bis-intercalator targeting of DNA triplex junctions enabling dual inhibition of topoisomerase I and oncogene transcription.Nucleic acids research · 2026Article
- FOXO3a upregulates DNA repair activities by transcriptional activation of target genes and provides the resistance to gamma radiation and the extension of lifespan in mouse.Biogerontology · 2025Article
- Derivatives of 9-phosphorylated acridine as butyrylcholinesterase inhibitors with antioxidant activity and the ability to inhibit β-amyloid self-aggregation: potential therapeutic agents for Alzheimer's disease.Frontiers in pharmacology · 2023Article
- Molecular Lysine Tweezers Counteract Aberrant Protein Aggregation.Frontiers in chemistry · 2019Review
- Molecular Modeling of Indeno [1, 2-b] Quinoline-9, 11-Diones as Cytotoxic Agents.Iranian journal of pharmaceutical research : IJPR · 2018Article
- Recent Advances in Developing Small Molecules Targeting Nucleic Acid.International journal of molecular sciences · 2016Review
- The impact of DNA intercalators on DNA and DNA-processing enzymes elucidated through force-dependent binding kinetics.Nature communications · 2015Article
- DNA Recognition by a Novel Bis-Intercalator, Potent Anticancer Drug XR5944.Current topics in medicinal chemistry · 2015Review
- Structure-based DNA-targeting strategies with small molecule ligands for drug discovery.Medicinal research reviews · 2013Review
- Ligand binding mode to duplex and triplex DNA assessed by combining electrospray tandem mass spectrometry and molecular modeling.Journal of the American Society for Mass Spectrometry · 2007Article
- X-ray crystallographic study of DNA duplex cross-linking: simultaneous binding to two d(CGTACG)2 molecules by a bis(9-aminoacridine-4-carboxamide) derivative.Nucleic acids research · 2006Article
- Stability of the I-motif structure is related to the interactions between phosphodiester backbones.Biophysical journal · 2003Article
- Structural perturbations in DNA caused by bis-intercalation of ditercalinium visualised by atomic force microscopy.Nucleic acids research · 2002Article
- Oligonucleotides form a duplex with non-helical properties on a positively charged surface.Nucleic acids research · 2001Article
- Double bands in DNA gel electrophoresis caused by bis-intercalating dyes.Nucleic acids research · 1995Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ditercalinium is a synthetic anticancer drug that binds to DNA by bis-intercalation and activates DNA repair processes. In prokaryotes, noncovalent DNA-ditercalinium complexes are incorrectly recognized by the uvrABC repair system as covalent lesions on DNA. In eukaryotes, mitochondrial DNA is degraded by excess and futile DNA repair. Using x-ray crystallography, we have determined, to 1.7 A resolution, the three-dimensional structure of a complex of ditercalinium bound to the double-stranded DNA fragment [d(CGCG)]2. The DNA in the complex with ditercalinium is kinked (by 15 degrees) and severely unwound (by 36 degrees) with exceptionally wide major and minor grooves. Recognition of the DNA-ditercalinium complex by uvrABC in prokaryotes, and by mitochondrial DNA repair systems in eukaryotes, might be related to drug-induced distortion of the DNA helix.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.