ArticleProceedings of the National Academy of Sciences of the United States of America1991
Methylation patterns of testis-specific genes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Analysis of Notch1 signaling in mammalian sperm development.BMC research notes · 2023Article
- Transgenerational sperm DNA methylation epimutation developmental origins following ancestral vinclozolin exposure.Epigenetics · 2019Article
- Developmental origins of transgenerational sperm DNA methylation epimutations following ancestral DDT exposure.Developmental biology · 2019Article
- Article
- Article
- In vivo analysis of developmentally and evolutionarily dynamic protein-DNA interactions regulating transcription of the Pgk2 gene during mammalian spermatogenesis.Molecular and cellular biology · 2007Article
- Characterization of a human regulatory subunit of protein phosphatase 3 gene (PPP3RL) expressed specifically in testis.Molecular biology reports · 2005Article
- Strengths and weaknesses of EST-based prediction of tissue-specific alternative splicing.BMC genomics · 2004Article
- Genomic analysis of the mouse protamine 1, protamine 2, and transition protein 2 gene cluster reveals hypermethylation in expressing cells.Mammalian genome : official journal of the International Mammalian Genome Society · 1997Article
- Regulation of Pdha-2 expression is mediated by proximal promoter sequences and CpG methylation.Molecular and cellular biology · 1997Article
- A truncated herpes simplex virus thymidine kinase phosphorylates thymidine and nucleoside analogs and does not cause sterility in transgenic mice.Molecular and cellular biology · 1995Article
- Characterization of mutations induced by ethylnitrosourea in seminiferous tubule germ cells of transgenic B6C3F1 mice.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- The ontogeny of allele-specific methylation associated with imprinted genes in the mouse.The EMBO journal · 1993Article
- Perinatal and multigenerational effect of carcinogens: possible contribution to determination of cancer susceptibility.Environmental health perspectives · 1992Review
- DNA methyltransferase is developmentally expressed in replicating and non-replicating male germ cells.Nucleic acids research · 1992Article
- The CpG island of chicken alpha-globin genes contains no signals sufficient for the maintenance of its nonmethylated state in transgenic mouse genome.Doklady. Biochemistry and biophysicsArticle
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3 authors.
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Abstract
The methylation patterns of genes expressed in the mouse male germ line have been examined. Int-1, Hox-2.1, and Prm-1, all of which contain 5' CpG islands, were found to be completely unmethylated at many sites in these domains, both in somatic tissues and in sperm DNA. Many other testis-specific genes have a similar structure and are probably also constitutively unmethylated. Pgk-2, a non-CpG-island gene, is similar to somatic tissue-specific genes in that it is highly methylated in nonexpressing cell types but undermethylated in pachytene spermatocytes and round spermatids, where it is actively transcribed. At later stages of spermatogenesis, however, the gene becomes remethylated and thus acquires the full modification pattern in sperm DNA. In all these cases, the sperm DNA that emerges from the testis does not contain any germ-line-specific unmethylated sites and thus carries the methylation pattern typical of that in somatic tissues.
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