ArticleJournal of Alzheimer's disease : JAD2010
The neuroprotective peptide NAP does not directly affect polymerization or dynamics of reconstituted neural microtubules.
Article in Journal of Alzheimer's disease : JAD, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- ADNP Functions During Early Brain Development and Their Relevance to ASD and ADNP Syndrome.International journal of molecular sciences · 2026Review
- Pharmacological Potential of Bioactive Peptides for the Treatment of Diseases Associated with Alzheimer's and Brain Disorders.Current molecular medicine · 2024Review
- Natural Plant Materials as a Source of Neuroprotective Peptides.Current medicinal chemistry · 2024Review
- Chromatin remodeler Activity-Dependent Neuroprotective Protein (ADNP) contributes to syndromic autism.Clinical epigenetics · 2023Review
- Microtubule Dysfunction: A Common Feature of Neurodegenerative Diseases.International journal of molecular sciences · 2020Review
- Crossing the blood-brain-barrier with nanoligand drug carriers self-assembled from a phage display peptide.Nature communications · 2019Article
- Reduction of aluminum ion neurotoxicity through a small peptide application - NAP treatment of Alzheimer's disease.Journal of food and drug analysis · 2019Article
- ADNP, a Microtubule Interacting Protein, Provides Neuroprotection Through End Binding Proteins and Tau: An Amplifier Effect.Frontiers in molecular neuroscience · 2018Article
- Repositioning Microtubule Stabilizing Drugs for Brain Disorders.Frontiers in cellular neuroscience · 2018Review
- ADNP/NAP dramatically increase microtubule end-binding protein-Tau interaction: a novel avenue for protection against tauopathy.Molecular psychiatry · 2017Article
- Notch signalling in adult neurons: a potential target for microtubule stabilization.Therapeutic advances in neurological disorders · 2013Article
- Therapeutic strategies for tau mediated neurodegeneration.Journal of neurology, neurosurgery, and psychiatry · 2013Review
- Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies.Journal of medicinal chemistry · 2012Review
- Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Modeling the effects of drug binding on the dynamic instability of microtubules.Physical biology · 2011Article
- Strategies for diminishing katanin-based loss of microtubules in tauopathic neurodegenerative diseases.Human molecular genetics · 2011Article
- A molecular and structural mechanism for G protein-mediated microtubule destabilization.The Journal of biological chemistry · 2011Article
- Maytansine and cellular metabolites of antibody-maytansinoid conjugates strongly suppress microtubule dynamics by binding to microtubules.Molecular cancer therapeutics · 2010Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
NAP (Asn-Ala-Pro-Val-Ser-Ile-Pro-Gln) is a neuroprotective peptide that shows cognitive protection in patients with amnestic mild cognitive impairment, a precursor to Alzheimer's disease. NAP exhibits potent neuroprotective properties in several in vivo and cellular models of neural injury. While NAP has been found in many studies to affect microtubule assembly and/or stability in neuronal and glial cells at fM concentrations, it has remained unclear whether NAP acts directly or indirectly on tubulin or microtubules. We analyzed the effects of NAP (1 fM-1 microM) on the assembly of reconstituted bovine brain microtubules in vitro and found that it did not significantly (p< 0.05) alter polymerization of either purified tubulin or of a mixture of tubulin and unfractionated microtubule-associated proteins. NAP also had no significant effect (p < 0.05) on the growing and shortening dynamics of steady-state microtubules at their plus ends, nor did it alter the polymerization or dynamics of microtubules assembled in the presence of 3-repeat or 4-repeat tau. Thus, the neuroprotective activity of NAP does not appear to involve a direct action on the polymerization or dynamics of purified tubulin or microtubules.
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