ArticleProceedings of the National Academy of Sciences of the United States of America1991
Identification of a T-cell-specific enhancer at the locus encoding T-cell antigen receptor gamma chain.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- Regulation of T-cell Receptor Gene Expression by Three-Dimensional Locus Conformation and Enhancer Function.International journal of molecular sciences · 2020Review
- The interleukin 7 receptor is required for T cell receptor gamma locus accessibility to the V(D)J recombinase.The Journal of experimental medicine · 2000Article
- Defective development of gamma/delta T cells in interleukin 7 receptor-deficient mice is due to impaired expression of T cell receptor gamma genes.The Journal of experimental medicine · 1999Article
- A novel element upstream of the Vgamma2 gene in the murine T cell receptor gamma locus cooperates with the 3' enhancer to act as a locus control region.The Journal of experimental medicine · 1999Article
- Interleukin 7 receptor control of T cell receptor gamma gene rearrangement: role of receptor-associated chains and locus accessibility.The Journal of experimental medicine · 1998Article
- Functional analysis of the V gamma 3 promoter of the murine gamma delta T-cell receptor.Molecular and cellular biology · 1994Article
- Identification and characterization of an Alu-containing, T-cell-specific enhancer located in the last intron of the human CD8 alpha gene.Molecular and cellular biology · 1993Article
- Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions.Molecular and cellular biology · 1993Article
- The ht beta gene encodes a novel CACCC box-binding protein that regulates T-cell receptor gene expression.Molecular and cellular biology · 1993Article
- Ordered rearrangement of variable region genes of the T cell receptor gamma locus correlates with transcription of the unrearranged genes.The Journal of experimental medicine · 1993Article
- SEF1 binding is important for T cell specific enhancers of genes for T cell receptor-CD3 subunits.Nucleic acids research · 1992Article
- A phorbol ester response element within the human T-cell receptor beta-chain enhancer.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Differential expression of subspecies of polyomavirus and murine leukemia virus enhancer core binding protein, PEBP2, in various hematopoietic cells.Japanese journal of cancer research : Gann · 1992Article
- Functional dissection of the lck proximal promoter.Molecular and cellular biology · 1992Article
- Identification and characterization of a T-cell-specific enhancer adjacent to the murine CD4 gene.Molecular and cellular biology · 1991Article
- The human enhancer-binding protein Gata3 binds to several T-cell receptor regulatory elements.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- New nucleotide sequence data on the EMBL File Server.Nucleic acids research · 1991Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The gamma delta and alpha beta T-cell antigen receptor (TCR) heterodimers are expressed in a lineage-specific, mutually exclusive manner. Regulation of expression occurs at the transcriptional level. A 13-kilobase (kb) stretch of DNA encompassing variable-joining-constant segments V gamma 4-J gamma 1-C gamma 1 of the murine gamma-chain gene was examined for the presence of transcriptional enhancing elements by a transient transfection assay. DNA fragments from this region were inserted into a test plasmid containing a heterologous promoter fused to the human growth hormone gene. An 1800-base-pair (bp) fragment located 3 kb 3' to C gamma exon III was found to display enhancing activity in several T-cell lines. Maximum enhancing activity could be localized further to fragments as small as 400 bp in some cell lines. Nucleotide sequence analysis of this 400-bp segment revealed homologies to previously described core enhancer elements and to other TCR gene enhancers. The TCR gamma-chain gene enhancer is active in both gamma delta and alpha beta T cells, indicating that it is not primarily responsible for lineage-specificity of expression, but it is inactive in non-T-cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.