ArticleThe Plant cell2010
Tomato 14-3-3 protein 7 positively regulates immunity-associated programmed cell death by enhancing protein abundance and signaling ability of MAPKKK {alpha}.
Article in The Plant cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed, 156 citations in OpenAlex.
- MtGRF8 interacts with MtSymCRK and prevents early bacteroid death during Medicago - Sinorhizobium symbiosis.The New phytologist · 2026Article
- Tomato Yellow Leaf Curl Virus C4 Suppresses Antiviral Immunity by Targeting the 14-3-3 Protein SlTFT2.Molecular plant pathology · 2026Article
- 14-3-3 proteins: Central hubs in plant development and stress adaptation.Journal of integrative plant biology · 2026Review
- The CBP60b-14-3-3 functional module regulates immunity in arabidopsis.Frontiers in plant science · 2026Article
- Function and defense mechanisms of wheat 14-3-3 protein TaGF14a in stripe rust resistance.BMC biology · 2025Article
- Article
- The 14-3-3 protein CaTFT7 interacts with transcription factor CaHDZ27 to positively regulate pepper immunity againstHorticulture research · 2025Article
- An Insect Effector Mimics Its Host Immune Regulator to Undermine Plant Immunity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A 14-3-3 Protein Ca16R Acts Positively in Pepper Immunity againstPlants (Basel, Switzerland) · 2024Article
- Potato virus Y viral protein 6K1 inhibits the interaction between defense proteins during virus infection.Plant physiology · 2024Article
- Formation of HopQ1:14-3-3 complex in the host cytoplasm modulates nuclear import rate ofFrontiers in plant science · 2024Article
- Functional Characterization ofMicrobiology spectrum · 2023Article
- 14-3-3 proteins facilitate the activation of MAP kinase cascades by upstream immunity-related kinases.The Plant cell · 2023Article
- TheInternational journal of molecular sciences · 2023Article
- Dynamic changes of the Prf/Pto tomato resistance complex following effector recognition.Nature communications · 2023Article
- Overexpression ofFrontiers in plant science · 2023Article
- Article
- A secreted ribonuclease effector from Verticillium dahliae localizes in the plant nucleus to modulate host immunity.Molecular plant pathology · 2022Article
- Overexpression ofInternational journal of molecular sciences · 2022Article
- Metaeffector interactions modulate the type III effector-triggered immunity load of Pseudomonas syringae.PLoS pathogens · 2022Article
3 more citing papers are in PubMed but not listed here.
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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Programmed cell death (PCD) is triggered when Pto, a Ser-Thr protein kinase, recognizes either the AvrPto or AvrPtoB effector from Pseudomonas syringae pv tomato. This PCD requires mitogen-activated protein kinase kinase kinase (MAPKKK alpha ) as a positive regulator in tomato (Solanum lycopersicum) and Nicotiana benthamiana. To examine how PCD-eliciting activity of the tomato MAPKKK alpha protein is regulated, we screened for MAPKKK alpha -interacting proteins in tomato and identified a 14-3-3 protein, TFT7. Virus-induced gene silencing using the TFT7 gene in N. benthamiana compromised both Pto- and MAPKKK alpha -mediated PCD, and coexpression of TFT7 with tomato MAPKKK alpha enhanced MAPKKK alpha -mediated PCD. TFT7 was also required for PCD associated with several other disease resistance proteins and contributed to resistance against P. syringae pv tomato. Coexpression of TFT7 with MAPKKK alpha in vivo caused increased accumulation of the kinase and enhanced phosphorylation of two MAP kinases. TFT7 protein contains a phosphopeptide binding motif that is present in human 14-3-3 epsilon, and substitutions in this motif abolished interaction with MAPKKK alpha in vivo and also the PCD-enhancing activity of TFT7. A 14-3-3 binding motif, including a putative phosphorylated Ser-535, is present in the C-terminal region of MAPKKK alpha. An S535A substitution in MAPKKK alpha reduced interaction with TFT7 and both PCD-eliciting ability and stability of MAPKKK alpha. Our results provide new insights into a role for 14-3-3 proteins in regulating immunity-associated PCD pathways in plants.
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