ArticleJournal of bacteriology2010
FimR and FimS: biofilm formation and gene expression in Porphyromonas gingivalis.
Article in Journal of bacteriology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Dihydromyricetin exhibits potent antibacterial activity and virulence factor inhibitory effects againstFrontiers in oral health · 2026Article
- Virulence diversity amongJournal of oral microbiology · 2026Review
- Magnetic microspheres mimicking certain functions of macrophages: Towards precise antibacterial potency for bone defect healing.Materials today. Bio · 2023Article
- Anti-biofilm activities of coumarin as quorum sensing inhibitor forJournal of oral microbiology · 2022Article
- Research progress on two-component signal transduction systems inHua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2021Review
- Quercetin inhibits virulence properties of Porphyromas gingivalis in periodontal disease.Scientific reports · 2020Article
- Identification of Streptococcus cristatus peptides that repress expression of virulence genes in Porphyromonas gingivalis.Scientific reports · 2017Article
- Genes Contributing toFrontiers in cellular and infection microbiology · 2017Article
- Article
- Characterization of a bacterial tyrosine kinase in Porphyromonas gingivalis involved in polymicrobial synergy.MicrobiologyOpen · 2014Article
- Genetic exchange of fimbrial alleles exemplifies the adaptive virulence strategy of Porphyromonas gingivalis.PloS one · 2014Article
- Regulon controlled by the GppX hybrid two component system in Porphyromonas gingivalis.Molecular oral microbiology · 2013Article
- Article
- Antibacterial action of polyphosphate on Porphyromonas gingivalis.Antimicrobial agents and chemotherapy · 2011Article
- Community signalling between Streptococcus gordonii and Porphyromonas gingivalis is controlled by the transcriptional regulator CdhR.Molecular microbiology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Porphyromonas gingivalis is a late-colonizing bacterium of the subgingival dental plaque biofilm associated with periodontitis. Two P. gingivalis genes, fimR and fimS, are predicted to encode a two-component signal transduction system comprising a response regulator (FimR) and a sensor histidine kinase (FimS). In this study, we show that fimS and fimR, although contiguous on the genome, are not part of an operon. We inactivated fimR and fimS in both the afimbriated strain W50 and the fimbriated strain ATCC 33277 and demonstrated that both mutants formed significantly less biofilm than their respective wild-type strains. Quantitative reverse transcription-real-time PCR showed that expression of fimbriation genes was reduced in both the fimS and fimR mutants of strain ATCC 33277. The mutations had no effect, in either strain, on the P. gingivalis growth rate or on the response to hydrogen peroxide or growth at pH 9, at 41 degrees C, or at low hemin availability. Transcriptome analysis using DNA microarrays revealed that inactivation of fimS resulted in the differential expression of 10% of the P. gingivalis genome (>1.5-fold; P < 0.05). Notably genes encoding seven different transcriptional regulators, including the fimR gene and three extracytoplasmic sigma factor genes, were differentially expressed in the fimS mutant.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.