ArticleJournal of immunology (Baltimore, Md. : 1950)2010
Physiological numbers of CD4+ T cells generate weak recall responses following influenza virus challenge.
Article in Journal of immunology (Baltimore, Md. : 1950), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Multivalent S2 subunit vaccines provide broad protection against Clade 1 sarbecoviruses in female mice.Nature communications · 2025Article
- Persistent B Cell-Derived MHC Class II Signaling Is Required for the Optimal Maintenance of Tissue-Resident Helper T Cells.ImmunoHorizons · 2024Article
- Interferon-γ production by Tfh cells is required for CXCR3Immunity · 2023Article
- Spatiotemporal resolution of germinal center Tfh cell differentiation and divergence from central memory CD4Nature communications · 2023Article
- Infant T cells are developmentally adapted for robust lung immune responses through enhanced T cell receptor signaling.Science immunology · 2021Article
- Influenza infection fortifies local lymph nodes to promote lung-resident heterosubtypic immunity.The Journal of experimental medicine · 2021Article
- Tolerance induction in memory CD4 T cells is partial and reversible.Immunology · 2021Article
- Airway Exosomes Released During Influenza Virus Infection Serve as a Key Component of the Antiviral Innate Immune Response.Frontiers in immunology · 2020Article
- Bach2 Negatively Regulates T Follicular Helper Cell Differentiation and Is Critical for CD4Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Fucosyltransferase Induction during Influenza Virus Infection Is Required for the Generation of Functional Memory CD4Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- The establishment of surrogates and correlates of protection: Useful tools for the licensure of effective influenza vaccines?Human vaccines & immunotherapeutics · 2018Review
- Sterilizing immunity to influenza virus infection requires local antigen-specific T cell response in the lungs.Scientific reports · 2016Article
- Competition within the virus-specific CD4 T-cell pool limits the T follicular helper response after influenza infection.Immunology and cell biology · 2016Article
- CD4 memory T cells develop and acquire functional competence by sequential cognate interactions and stepwise gene regulation.International immunology · 2016Article
- A novel therapeutic strategy of lipidated promiscuous peptide against Mycobacterium tuberculosis by eliciting Th1 and Th17 immunity of host.Scientific reports · 2016Article
- Heterosubtypic T-Cell Immunity to Influenza in Humans: Challenges for Universal T-Cell Influenza Vaccines.Frontiers in immunology · 2016Review
- Induction of microglia activation after infection with the non-neurotropic A/CA/04/2009 H1N1 influenza virus.PloS one · 2015Article
- Pathogen-related differences in the abundance of presented antigen are reflected in CD4+ T cell dynamic behavior and effector function in the lung.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Memory CD4 T cell-mediated immunity against influenza A virus: more than a little helpful.Archivum immunologiae et therapiae experimentalis · 2013Review
- Efficient generation and rapid isolation via stoplight recombination of Herpes simplex viruses expressing model antigenic and immunological epitopes.Journal of virological methods · 2012Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Naive and recall CD4(+) T cell responses were probed with recombinant influenza A viruses incorporating the OVA OT-II peptide. The extent of OT-II-specific CD4(+) T cell expansion was greater following primary exposure, with secondary challenge achieving no significant increase in numbers, despite higher precursor frequencies. Adoptive transfer experiments with OT-II TCR-transgenic T cells established that the predominant memory set is CD62L(hi), whereas the CD62L(lo) precursors make little contribution to the recall response. Unlike the situation described by other investigators, in which the transfer of very large numbers of in vitro-activated CD4 effectors can modify the disease process, providing CD62L(hi) or CD62L(lo) OT-II-specific T cells at physiological levels neither enhanced virus clearance nor altered clinical progression. Some confounding effects of the transgenic model were observed, with decreasing primary expansion efficiency correlating with greater numbers of transferred cells. This was associated with increased levels of mRNA for the proapoptotic molecule Bim in cells recovered following high-dose transfer. However, even with very low numbers of transferred cells, memory T cells did not expand significantly following secondary challenge. A similar result was recorded in mice primed and boosted to respond to an endogenous IA(b)-restricted epitope derived from the influenza virus hemagglutinin glycoprotein. Depletion of CD8(+) T cells during secondary challenge generated an increased accumulation of OT-II-specific T cells but only at the site of infection. Taken together, significant expansion was not a feature of these secondary influenza-specific CD4 T cell responses and the recall of memory did not enhance recovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.