ArticleThe Journal of biological chemistry2010
Pro-hormone secretogranin II regulates dense core secretory granule biogenesis in catecholaminergic cells.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 61 citations in OpenAlex.
- Scg2 drives corticospinal circuit reorganization with spinal premotor interneurons and astrocytes for motor recovery after stroke in mice.Nature communications · 2026Article
- Chromaffin Versus Platelet Granules: What We Have Learned From Chromaffin Cells for Human Studies.Journal of neurochemistry · 2026Review
- An adeno-associated virus gene therapy strategy for anti-obesity treatment by nanocarrier-based delivery systems.Journal of nanobiotechnology · 2025Article
- Estrogen-dependent expression and function of secretogranin 2a in female-specific peptidergic neurons.PNAS nexus · 2023Article
- Secretogranin II influences the assembly and function of MHC class I in melanoma.Experimental hematology & oncology · 2023Article
- Trafficking of hormones and trophic factors to secretory and extracellular vesicles: a historical perspective and new hypothesis.Extracellular vesicles and circulating nucleic acids · 2023Article
- Tuning the Size of Large Dense-Core Vesicles and Quantal Neurotransmitter Release via Secretogranin II Liquid-Liquid Phase Separation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Differential Expression of Secretogranins II and III in Canine Adrenal Chromaffin Cells and Pheochromocytomas.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2022Article
- Inside the Insulin Secretory Granule.Metabolites · 2021Review
- Coxsackievirus B Persistence Modifies the Proteome and the Secretome of Pancreatic Ductal Cells.iScience · 2019Article
- Dense-core vesicle biogenesis and exocytosis in neurons lacking chromogranins A and B.Journal of neurochemistry · 2018Article
- Expression of Secretogranin III in Chicken Endocrine Cells: Its Relevance to the Secretory Granule Properties of Peptide Prohormone Processing and Bioactive Amine Content.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2015Article
- The BAR domain protein PICK1 controls vesicle number and size in adrenal chromaffin cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- The neuroendocrine phenotype of gastric myofibroblasts and its loss with cancer progression.Carcinogenesis · 2014Article
- The granin VGF promotes genesis of secretory vesicles, and regulates circulating catecholamine levels and blood pressure.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Decreased cerebrospinal fluid secretogranin II concentrations in severe forms of bipolar disorder.Journal of psychiatry & neuroscience : JPN · 2013Article
- The regulated secretory pathway and human disease: insights from gene variants and single nucleotide polymorphisms.Frontiers in endocrinology · 2013Article
- The extended granin family: structure, function, and biomedical implications.Endocrine reviews · 2011Review
- A common genetic variant in the 3'-UTR of vacuolar H+-ATPase ATP6V0A1 creates a micro-RNA motif to alter chromogranin A processing and hypertension risk.Circulation. Cardiovascular genetics · 2011Article
- HID-1, a new component of the peptidergic signaling pathway.Genetics · 2011Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Processes underlying the formation of dense core secretory granules (DCGs) of neuroendocrine cells are poorly understood. Here, we present evidence that DCG biogenesis is dependent on the secretory protein secretogranin (Sg) II, a member of the granin family of pro-hormone cargo of DCGs in neuroendocrine cells. Depletion of SgII expression in PC12 cells leads to a decrease in both the number and size of DCGs and impairs DCG trafficking of other regulated hormones. Expression of SgII fusion proteins in a secretory-deficient PC12 variant rescues a regulated secretory pathway. SgII-containing dense core vesicles share morphological and physical properties with bona fide DCGs, are competent for regulated exocytosis, and maintain an acidic luminal pH through the V-type H(+)-translocating ATPase. The granulogenic activity of SgII requires a pH gradient along this secretory pathway. We conclude that SgII is a critical factor for the regulation of DCG biogenesis in neuroendocrine cells, mediating the formation of functional DCGs via its pH-dependent aggregation at the trans-Golgi network.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.