ArticleAmerican journal of epidemiology2010
Pesticide use and thyroid disease among women in the Agricultural Health Study.
Article in American journal of epidemiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
69 citing papers in PubMed, 3 syntheses or guidelines pooled it, 196 citations in OpenAlex.
- Exposure to pesticides and the risk of hypothyroidism: a systematic review and meta-analysis.BMC public health · 2023Pooled it
- Time for Re-Evaluating the Human Carcinogenicity of Ethylenedithiocarbamate Fungicides? A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Association between Female Reproductive Health and Mancozeb: Systematic Review of Experimental Models.International journal of environmental research and public health · 2020Pooled it
- Association of aryl hydrocarbon receptor gene polymorphisms with hashimoto's thyroiditis.Journal of endocrinological investigation · 2026Article
- Article
- Associations between persistent organic pollutants and thyroid-related hormones and homeostasis parameters in middle-aged to older men and postmenopausal women: The HCHS/SOL.Environmental research · 2025Article
- Concurrent associations of glyphosate, dithiocarbamate fungicides, and PFAS with body fat composition and BMI in adolescents from agricultural communities.Environmental research · 2025Article
- Quantitative phenolic profiling and protective effects of grape seed extract on mancozeb-induced cellular and genetic toxicity.Scientific reports · 2025Article
- What Is the Impact of Glyphosate on the Thyroid? An Updated Review.Biomedicines · 2025Review
- Occupational health complaints and demographic features of farmers exposed to agrochemicals during agricultural activity.BMC public health · 2025Article
- Polychlorinated Biphenyls (PCBS)-induced oxidative stress and inflammation in human thyrocytes: involvement of AhR and NRF-2/HO-1 pathway.Endocrine · 2025Article
- Cross-Sectional Examination of Thyroid Hormones and Environmental Exposure to Multiclass Pesticides in Women of Reproductive Age in China.Environmental health perspectives · 2024Article
- Association between pesticide exposure and thyroid function: analysis of Chinese and NHANES databases.Frontiers in public health · 2024Article
- The impact of the use of personal-protective-equipment on the minimization of effects of exposure to pesticides among farm-workers in India.Frontiers in public health · 2023Article
- Patterns of Thyroid Cancer Mortality and Incidence in Saudi Arabia: A 30-Year Study.Diagnostics (Basel, Switzerland) · 2022Article
- Correlation between Lindane Use and the Incidence of Thyroid Cancer in the United States: An Ecological Study.International journal of environmental research and public health · 2022Article
- Thyroid Cancer and Pesticide Use in a Central California Agricultural Area: A Case Control Study.The Journal of clinical endocrinology and metabolism · 2022Article
- Exposure to common-use pesticides, manganese, lead, and thyroid function among pregnant women from the Infants' Environmental Health (ISA) study, Costa Rica.The Science of the total environment · 2022Article
- Histopathological, immunohistochemical and biochemical alterations in liver tissue after fungicide-mancozeb exposures in Wistar albino rats.Acta cirurgica brasileira · 2022Article
- Comparison of Thyroid Hormone Levels between Women Farmers and Non-Farmers in Banten Indonesia.International journal of environmental research and public health · 2021Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Thyroid disease is common, and evidence of an association between organochlorine exposure and thyroid disease is increasing. The authors examined the cross-sectional association between ever use of organochlorines and risk of hypothyroidism and hyperthyroidism among female spouses (n = 16,529) in Iowa and North Carolina enrolled in the Agricultural Health Study in 1993-1997. They also assessed risk of thyroid disease in relation to ever use of herbicides, insecticides, fungicides, and fumigants. Prevalence of self-reported clinically diagnosed thyroid disease was 12.5%, and prevalence of hypothyroidism and hyperthyroidism was 6.9% and 2.1%, respectively. There was an increased odds of hypothyroidism with ever use of organochlorine insecticides (adjusted odds ratio (OR(adj)) = 1.2 (95% confidence interval (CI): 1.0, 1.6) and fungicides (OR(adj) = 1.4 (95% CI: 1.1, 1.8) but no association with ever use of herbicides, fumigants, organophosphates, pyrethroids, or carbamates. Specifically, ever use of the organochlorine chlordane (OR(adj) = 1.3 (95% CI: 0.99, 1.7), the fungicides benomyl (OR(adj) = 3.1 (95% CI: 1.9, 5.1) and maneb/mancozeb (OR(adj) = 2.2 (95% CI: 1.5, 3.3), and the herbicide paraquat (OR(adj) = 1.8 (95% CI: 1.1, 2.8) was significantly associated with hypothyroidism. Maneb/mancozeb was the only pesticide associated with both hyperthyroidism (OR(adj) = 2.3 (95% CI: 1.2, 4.4) and hypothyroidism. These data support a role of organochlorines, in addition to fungicides, in the etiology of thyroid disease among female spouses enrolled in the Agricultural Health Study.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.