ArticleCarcinogenesis2010
Tumor formation in a mouse model of colitis-associated colon cancer does not require COX-1 or COX-2 expression.
Article in Carcinogenesis, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 71 citations in OpenAlex.
- Mouse Models for Application in Colorectal Cancer: Understanding the Pathogenesis and Relevance to the Human Condition.Biomedicines · 2022Review
- Effects of Genetic and Pharmacologic Inhibition of COX-2 on Colitis-associated Carcinogenesis in Mice.Journal of cancer prevention · 2020Article
- Significance of Cyclooxygenase-2 in Oncogenesis.Journal of veterinary research · 2019Article
- Glucocorticoids promote the development of azoxymethane and dextran sulfate sodium-induced colorectal carcinoma in mice.BMC cancer · 2019Article
- Eicosanoid signaling in carcinogenesis of colorectal cancer.Cancer metastasis reviews · 2018Review
- Effect of Angelica sinensis Root Extract on Cancer Prevention in Different Stages of an AOM/DSS Mouse Model.International journal of molecular sciences · 2017Article
- TrkC promotes colorectal cancer growth and metastasis.Oncotarget · 2017Article
- miR-19a promotes colitis-associated colorectal cancer by regulating tumor necrosis factor alpha-induced protein 3-NF-κB feedback loops.Oncogene · 2017Article
- Cysteinyl leukotriene receptor 1 facilitates tumorigenesis in a mouse model of colitis-associated colon cancer.Oncotarget · 2017Article
- Article
- Mechanistic roles of epithelial and immune cell signaling during the development of colitis-associated cancer.Cancer research frontiers · 2016Article
- Therapeutic potential of cyclooxygenase-3 inhibitors in the management of glioblastoma.Journal of neuro-oncology · 2016Article
- Influence of myeloperoxidase on colon tumor occurrence in inflamed versus non-inflamed colons of Apc(Min/+) mice.Redox biology · 2015Article
- Berberine regulates AMP-activated protein kinase signaling pathways and inhibits colon tumorigenesis in mice.Molecular carcinogenesis · 2015Article
- Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment.Cell research · 2015Article
- Id1 Deficiency Protects against Tumor Formation in Apc(Min/+) Mice but Not in a Mouse Model of Colitis-Associated Colon Cancer.Cancer prevention research (Philadelphia, Pa.) · 2015Article
- The Hen or the Egg: Inflammatory Aspects of Murine MPN Models.Mediators of inflammation · 2015Review
- Colitis-associated neoplasia: molecular basis and clinical translation.Cellular and molecular life sciences : CMLS · 2014Review
- Novel non-cyclooxygenase inhibitory derivatives of naproxen for colorectal cancer chemoprevention.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2014Article
- HuR: a promising therapeutic target for angiogenesis.Gland surgery · 2014Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cyclooxygenase-2 (COX-2), a key enzyme of prostanoid biosynthesis, plays an important role in both hereditary and spontaneous colon cancer. Individuals with ulcerative colitis are also at high risk for colorectal cancer. To investigate the role of Cox-2 in colitis-associated colon cancer, we subjected Cox-2 luciferase-knock-in mice and Cox-2-knockout mice to a well-known mouse model of colitis-associated cancer in which animals are treated with a single-azoxymethane (AOM) injection followed by dextran sulfate sodium (DSS) administration. Tumors induced by AOM and DSS expressed significantly higher Cox-2 levels when compared with surrounding areas of colon, as detected both by luciferase reporter gene expression driven from the endogenous Cox-2 promoter and by western blotting of COX-2 protein in Cox-2 luciferase heterozygous knock-in mice. Immunofluorescence revealed that tumor stromal fibroblasts, macrophages and endothelial cells express COX-2 protein. In contrast, little COX-2 expression was observed in myofibroblasts or epithelial cells. Despite a significant elevation of COX-2 expression in AOM/DSS-induced colon tumors in wild-type mice, similar tumors developed in AOM/DSS-treated Cox-2(-/-)- and Cox-1(-/-)-knockout mice. These results indicate that cyclooxygenase-derived prostanoids are not major players in colitis-associated cancer. In contrast, tumor formation induced by multiple injections of AOM (with no DSS-induced colitis) did not occur in Cox-2(-/-)-knockout mice. Our data suggest that the mechanism of colorectal tumor promotion in colitis-associated cancer differs from the mechanism of tumor promotion for hereditary and sporadic colorectal cancer.
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