ArticleEnvironmental health perspectives2010
Particulate matter-induced airway hyperresponsiveness is lymphocyte dependent.
Article in Environmental health perspectives, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 62 citations in OpenAlex.
- Increases in ambient air pollutants during pregnancy are linked to increases in methylation of IL4, IL10, and IFNγ.Clinical epigenetics · 2022Article
- Effects of Air Pollutant Exposure on Exacerbation Severity in Asthma Patients with or without Reversible Airflow Obstruction.Journal of asthma and allergy · 2021Article
- Lactic Acid Bacteria Ameliorate Diesel Exhaust Particulate Matter-Exacerbated Allergic Inflammation in a Murine Model of Asthma.Life (Basel, Switzerland) · 2020Article
- Systemic Exposure to Air Pollution Induces Oxidative Stress and Inflammation in Mouse Brain, Contributing to Neurodegeneration Onset.International journal of molecular sciences · 2020Article
- Respiratory Health Effects of Exposure to Ambient Particulate Matter and Bioaerosols.Comprehensive Physiology · 2019Article
- TH17-Induced Neutrophils Enhance the Pulmonary Allergic Response Following BALB/c Exposure to House Dust Mite Allergen and Fine Particulate Matter From California and China.Toxicological sciences : an official journal of the Society of Toxicology · 2018Article
- Urban particulate matter stimulation of human dendritic cells enhances priming of naive CD8 T lymphocytes.Immunology · 2018Article
- Unique pulmonary immunotoxicological effects of urban PM are not recapitulated solely by carbon black, diesel exhaust or coal fly ash.Environmental research · 2018Article
- The Aryl Hydrocarbon Receptor and Tumor Immunity.Frontiers in immunology · 2018Review
- Exposure to NOClinical epigenetics · 2018Article
- Breaking Steroid Resistance: Effect of Vitamin D on IL-23.American journal of respiratory cell and molecular biology · 2017Article
- Vitamin D Counteracts an IL-23-Dependent IL-17AAmerican journal of respiratory cell and molecular biology · 2017Article
- Elevated microRNA-135a is associated with pulmonary arterial hypertension in experimental mouse model.Oncotarget · 2017Article
- The acute airway inflammation induced by PMScientific reports · 2017Article
- The effect of size-segregated ambient particulate matter on Th1/Th2-like immune responses in mice.PloS one · 2017Article
- Article
- Proximity to a Major Road and Plasma Cytokines in School-Aged Children.Pediatric allergy, immunology, and pulmonology · 2016Article
- Urban Particulate Matter-Activated Human Dendritic Cells Induce the Expansion of Potent Inflammatory Th1, Th2, and Th17 Effector Cells.American journal of respiratory cell and molecular biology · 2016Article
- Interleukin 13- and interleukin 17A-induced pulmonary hypertension phenotype due to inhalation of antigen and fine particles from air pollution.Pulmonary circulation · 2014Article
- Perspective: ambient air pollution: inflammatory response and effects on the lung's vasculature.Pulmonary circulation · 2014Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundExposure to airborne particulate matter (PM), a major component of air pollution, has been associated with increases in both exacerbations of and hospitalizations for asthma. We have previously shown that exposure to ambient PM collected in urban Baltimore (AUB) induces airway hyperresponsiveness (AHR), eosinophilic and neutrophilic inflammation, and the recruitment of T cells. However, the mechanism(s) by which it induces these features of asthma remains unknown.
objectiveWe investigated whether T lymphocytes play a role in AUB-induced AHR.
methodsWe compared the effects of AUB exposure on the allergic phenotype in wild-type (WT) BALB/c mice and in mice deficient in recombinase-activating gene-1 (Rag1-/-) that lack mature lymphocytes.
resultsWe found that exposure of WT mice to AUB induced AHR concomitant with increases in the numbers of bronchoalveolar lavage (BAL) fluid lymphocytes, eosinophils, neutrophils, and mucus-containing cells in the lungs of WT mice. Interestingly, we show for the first time that these effects were associated with significant elevations in interleukin (IL)-17A, IL-17F, and T-helper 2 cell (TH2) (IL-13, IL-5) cytokine levels in lung cells, as well as reductions in the levels of the suppressive cytokine IL-10. Interestingly, Rag1-/- mice failed to develop AUB-induced AHR; however, AUB-induced BAL fluid cellularity, and mucus cell changes were only partially inhibited in Rag1-/- mice.
conclusionsTaken together, our results suggest that AUB exposure increases the pathophysiological features of asthma via activation of lymphocyte-dependent pathways. These results provide a plausible biological mechanism for the strong association between PM exposure and the increased severity of asthma.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.