ReviewDNA repair2010
Distinct roles of RECQ1 in the maintenance of genomic stability.
Review in DNA repair, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 39 citations in OpenAlex.
- Targeting the Werner syndrome protein in microsatellite instability cancers: mechanisms and therapeutic potential.Clinical and experimental medicine · 2025Review
- GermlineFrontiers in medicine · 2024Article
- ID3 promotes homologous recombination via non-transcriptional and transcriptional mechanisms and its loss confers sensitivity to PARP inhibition.Nucleic acids research · 2021Article
- Low expression of RECQL is associated with poor prognosis in Chinese breast cancer patients.BMC cancer · 2018Article
- RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma.Leukemia · 2017Article
- Clinicopathological and Functional Significance of RECQL1 Helicase in Sporadic Breast Cancers.Molecular cancer therapeutics · 2017Article
- Review
- Site-directed mutants of human RECQ1 reveal functional importance of the zinc binding domain.Mutation research · 2016Article
- Mutations in RECQL Gene Are Associated with Predisposition to Breast Cancer.PLoS genetics · 2015Article
- RECQL: a new breast cancer susceptibility gene.Cell cycle (Georgetown, Tex.) · 2015Article
- Altered RECQ Helicase Expression in Sporadic Primary Colorectal Cancers.Translational oncology · 2013Article
- Human RECQ1 interacts with Ku70/80 and modulates DNA end-joining of double-strand breaks.PloS one · 2013Article
- Both OsRecQ1 and OsRDR1 are required for the production of small RNA in response to DNA-damage in rice.PloS one · 2013Article
- Probing Genome Maintenance Functions of human RECQ1.Computational and structural biotechnology journal · 2013Review
- RECQ1 is required for cellular resistance to replication stress and catalyzes strand exchange on stalled replication fork structures.Cell cycle (Georgetown, Tex.) · 2012Article
- DNA mismatch repair network gene polymorphism as a susceptibility factor for pancreatic cancer.Molecular carcinogenesis · 2012Article
- Superfamily 2 helicases.Frontiers in bioscience (Landmark edition) · 2012Review
- Article
- DNA repair and replication fork helicases are differentially affected by alkyl phosphotriester lesion.The Journal of biological chemistry · 2012Article
- The human Suv3 helicase interacts with replication protein A and flap endonuclease 1 in the nucleus.The Biochemical journal · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Five human RecQ helicases (WRN, BLM, RECQ4, RECQ5, RECQ1) exist in humans. Of these, three are genetically linked to diseases of premature aging and/or cancer. Neither RECQ1 nor RECQ5 has yet been implicated in a human disease. However, cellular studies and genetic analyses of model organisms indicate that RECQ1 (and RECQ5) play an important role in the maintenance of genomic stability. Biochemical studies of purified RECQ1 protein demonstrate that the enzyme catalyzes DNA unwinding and strand annealing, and these activities are likely to be important for its role in DNA repair. RECQ1 also physically and functionally interacts with proteins involved in genetic recombination. In this review, we will summarize our current knowledge of RECQ1 roles in cellular nucleic acid metabolism and propose avenues of investigation for future studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.