ArticleHeart rhythm2010
Purkinje activation precedes myocardial activation following defibrillation after long-duration ventricular fibrillation.
Article in Heart rhythm, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Mapping and ablation of ventricular fibrillation substrate.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Review
- Left Bundle Branch Area Antitachycardia Pacing Improves Success Rate Compared to Right Ventricular Antitachycardia Pacing.JACC. Clinical electrophysiology · 2026Article
- Effects of Purkinje Fiber Conduction Block on Cardiac Pump Function: Computational Modeling Study.Bioengineering (Basel, Switzerland) · 2026Article
- Effect of flunarizine on defibrillation outcomes and early refibrillation in a canine model of prolonged ventricular fibrillation.Experimental physiology · 2019Article
- Undersensing of ventricular fibrillation by a biventricular implantable cardioverter-defibrillator: What is the cause and the troubleshooting?Journal of arrhythmia · 2019Article
- Spatiotemporal Progression of Early Human Ventricular Fibrillation.JACC. Clinical electrophysiology · 2017Article
- Rotor stability separates sustained ventricular fibrillation from self-terminating episodes in humans.Journal of the American College of Cardiology · 2014Article
- Endocardial focal activation originating from Purkinje fibers plays a role in the maintenance of long duration ventricular fibrillation.Croatian medical journal · 2014Article
- Placement of implantable cardioverter-defibrillators in paediatric and congenital heart defect patients: a pipeline for model generation and simulation prediction of optimal configurations.The Journal of physiology · 2013Article
- Cardiac optogenetics.American journal of physiology. Heart and circulatory physiology · 2013Review
- Three-dimensional mechanisms of increased vulnerability to electric shocks in myocardial infarction: altered virtual electrode polarizations and conduction delay in the peri-infarct zone.The Journal of physiology · 2012Article
- Mechanisms of defibrillation.Annual review of biomedical engineering · 2010Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundWhile reentry within the ventricular myocardium (VM) is responsible for the maintenance of short-duration ventricular fibrillation (SDVF; VF duration <1 minute), Purkinje fibers (PFs) are important in the maintenance of long-duration ventricular fibrillation (LDVF; VF duration >1 minute).
objectiveThe purpose of this study was to test the hypothesis that the mechanisms of defibrillation may also be different for SDVF and LDVF.
methodsA multielectrode basket catheter was deployed in the left ventricle of eight beagles. External defibrillation shocks were delivered with a ramp-up protocol after SDVF (20 seconds) and LDVF (150 seconds). Earliest VM and PF activations were identified after the highest energy shock that failed to terminate VF and the successful shock.
resultsDefibrillation was successful after 36 +/- 12 and 181 +/- 14 seconds for SDVF and LDVF, respectively. The time after shock delivery until earliest activation was detected for failed shocks and was significantly longer after LDVF (138.7 +/- 24.1 ms) than after SDVF (75.6 +/- 8.7 ms). Earliest postshock activation after SDVF typically initiated in the VM (14 of 16 episodes), while it always initiated in the PF (16 of 16 episodes) after LDVF. Sites of earliest activity during sinus rhythm correlated with sites of earliest postshock activation for PF-led cycles but not for VM-led cycles.
conclusionEarliest recorded postshock activation is in the Purkinje system after LDVF but not after SDVF. This difference raises the possibility that the optimal defibrillation strategy is different for SDVF and LDVF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.