ArticleJournal of autoimmunity2010
Peripherin-IgG association with neurologic and endocrine autoimmunity.
Article in Journal of autoimmunity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- Intravenous Immunoglobulin Therapy in Patients With Painful Idiopathic Small Fiber Neuropathy.Neurology · 2021Trial
- Intravenous immunoglobulin therapy for small fiber neuropathy: study protocol for a randomized controlled trial.Trials · 2016Trial
- Novel methods for neural IgG characterization and validation in autoimmune neurologic disorders.Journal of immunological methods · 2026Review
- Peripherin, A New Promising Biomarker in Neurological Disorders.The European journal of neuroscience · 2025Review
- Role of the Intermediate Filament Protein Peripherin in Health and Disease.International journal of molecular sciences · 2022Review
- Neuroimmunogastroenterology: At the Interface of Neuroimmunology and Gastroenterology.Frontiers in neurology · 2020Review
- Paraneoplastic neuronal intermediate filament autoimmunity.Neurology · 2018Article
- Discovery of Phosphorylated Peripherin as a Major Humoral Autoantigen in Type 1 Diabetes Mellitus.Cell chemical biology · 2016Article
- Article
- Immunotherapy trial as diagnostic test in evaluating patients with presumed autoimmune gastrointestinal dysmotility.Neurogastroenterology and motility · 2014Article
- In vivo detection of peripherin-specific autoreactive B cells during type 1 diabetes pathogenesis.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Evidence of small-fiber polyneuropathy in unexplained, juvenile-onset, widespread pain syndromes.Pediatrics · 2013Article
- Humoral autoimmunity in type 1 diabetes: prediction, significance, and detection of distinct disease subtypes.Cold Spring Harbor perspectives in medicine · 2012Review
- Islet autoantigens: structure, function, localization, and regulation.Cold Spring Harbor perspectives in medicine · 2012Review
- Small-fibre neuropathies--advances in diagnosis, pathophysiology and management.Nature reviews. Neurology · 2012Review
- Environmental pathways to autoimmune diseases: the cases of primary biliary cirrhosis and multiple sclerosis.Archives of medical science : AMS · 2011Article
- Neural autoantibody evaluation in functional gastrointestinal disorders: a population-based case-control study.Digestive diseases and sciences · 2011Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Peripherin-IgG has been reported a pertinent autoantibody in non-obese type 1 diabetic (NOD) mice. However, it has not previously been recognized in any human disease. In blinded evaluation of serum for markers of neurological autoimmunity in a high-volume diagnostic laboratory, we incidentally identified 26 patients (61% female) with an IgG that bound selectively to neural elements in enteric ganglia, sympathetic nerve trunks and discrete nerve tracts in mid-brain and hind-brain. The target antigen was identified as peripherin, a 55kDa - type III intermediate filament protein. Review of clinical histories revealed that 54% of seropositive patients had dysautonomia (predominantly gastrointestinal dysmotility), 30% had neuropathies with varied sensory symptoms and 35% had clinical or serological evidence of endocrinopathy (type 1 diabetes, thyroiditis or premature ovarian failure). Collectively, 73% had autonomic dysfunction or endocrinopathy. None of 173 healthy subjects was seropositive. Subsequent western blot evaluation of archival sera from patients with small fiber/autonomic neuropathies (with or without endocrinopathy) revealed a 33% seropositivity rate for peripherin-IgG. Our further demonstration that peripherin-immunoreactive autonomic fibers in pancreas, thyroid and ovary are juxtaposed to endocrine epithelium, complement our clinical observations in suggesting that neuronal elements may be a pertinent initial target for immune attack in multiple forms of endocrine autoimmunity (intermolecular epitope spreading). It remains to be determined whether or not peripherin-IgG is predictive for development of small fiber neuropathy (autonomic or somatic).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.