ArticleJournal of structural biology2010
Insights into the domain and repeat architecture of target of rapamycin.
Article in Journal of structural biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- An expanded clinical spectrum of hypoinsulinaemic hypoketotic hypoglycaemia.Orphanet journal of rare diseases · 2023Article
- Rapamycin, the only drug that has been consistently demonstrated to increase mammalian longevity. An update.Experimental gerontology · 2023Review
- Identification of defined structural elements within TOR2 kinase required for TOR complex 2 assembly and function inMolecular biology of the cell · 2022Article
- Oligo-carrageenan kappa increases glucose, trehalose and TOR-P and subsequently stimulates the expression of genes involved in photosynthesis, and basal and secondary metabolisms in Eucalyptus globulus.BMC plant biology · 2019Article
- NMR- and MD simulation-based structural characterization of the membrane-associating FATC domain of ataxia telangiectasia mutated.The Journal of biological chemistry · 2019Article
- Redesigning TOR Kinase to Explore the Structural Basis for TORC1 and TORC2 Assembly.Biomolecules · 2018Article
- Control of RNA polymerase II-transcribed genes by direct binding of TOR kinase.Current genetics · 2018Review
- Weighing In on mTOR Complex 2 Signaling: The Expanding Role in Cell Metabolism.Oxidative medicine and cellular longevity · 2018Review
- Emerging Role of mTOR Signaling-Related miRNAs in Cardiovascular Diseases.Oxidative medicine and cellular longevity · 2018Review
- Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2.Nature communications · 2017Article
- mTOR function and therapeutic targeting in breast cancer.American journal of cancer research · 2017Review
- Using HHsearch to tackle proteins of unknown function: A pilot study with PH domains.Traffic (Copenhagen, Denmark) · 2016Article
- Tor forms a dimer through an N-terminal helical solenoid with a complex topology.Nature communications · 2016Article
- Regulation of the Target of Rapamycin and Other Phosphatidylinositol 3-Kinase-Related Kinases by Membrane Targeting.Membranes · 2015Review
- Article
- NMR- and circular dichroism-monitored lipid binding studies suggest a general role for the FATC domain as membrane anchor of phosphatidylinositol 3-kinase-related kinases (PIKK).The Journal of biological chemistry · 2013Article
- Functional and genomic analyses of alpha-solenoid proteins.PloS one · 2013Article
- Rpn1 and Rpn2 coordinate ubiquitin processing factors at proteasome.The Journal of biological chemistry · 2012Article
- Plant TOR signaling components.Plant signaling & behavior · 2011Review
- Rapamycin passes the torch: a new generation of mTOR inhibitors.Nature reviews. Drug discovery · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
A simple and efficient protein sequence analysis strategy was developed to predict the number and location of structural repeats in the TOR protein. This strategy uses multiple HHpred alignments against proteins of known 3D structure to enable protein repeats referenced from the 3D structure to be traced back to the query protein sequence by using user-directed repeat assignments. The HHpred strategy performed with high sensitivity by predicting 100% of the repeat units within a test set of HEAT- and TPR-repeat-containing proteins of known three-dimensional structure. The HHpred strategy predicts that TOR contains 32 tandem HEAT repeats extending from the N-terminus to the FAT domain, which is itself comprised of 16 tandem TPR repeats. These findings were used to assemble a 3D atomic model for the TOR protein.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.