ArticleJournal of immunological methods2010
Overcoming the hurdles in using mouse genetic models that block TGF-beta signaling.
Article in Journal of immunological methods, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- CD163 and Tim-4 identify resident intestinal macrophages that are spatially regulated by TGF-β.The Journal of experimental medicine · 2026Article
- Article
- TGF-β in inflammatory bowel disease: a key regulator of immune cells, epithelium, and the intestinal microbiota.Journal of gastroenterology · 2017Review
- Article
- Intrinsic TGF-β signaling promotes age-dependent CD8+ T cell polyfunctionality attrition.The Journal of clinical investigation · 2014Article
- Article
- Truncated form of TGF-βRII, but not its absence, induces memory CD8+ T cell expansion and lymphoproliferative disorder in mice.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Dendritic cell-specific disruption of TGF-β receptor II leads to altered regulatory T cell phenotype and spontaneous multiorgan autoimmunity.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Therapeutic blockade of transforming growth factor beta fails to promote clearance of a persistent viral infection.Journal of virology · 2012Article
- Environmental and antigen receptor-derived signals support sustained surveillance of the lungs by pathogen-specific cytotoxic T lymphocytes.Journal of virology · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The recent recognition of the importance of transforming growth factor beta (TGF-beta) in mediating many cellular immune functions has popularized the use of mouse models where TGF-beta signaling is blocked in specific cell types. However, there are some caveats affiliated with each model. Here we describe and show evidence for some of the limitations of these models and provide insight into ways to improve the utility of these animals for in vivo studies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.