Evidence map›Paper›PMID 20060812›Full record

ArticleBiochemical and biophysical research communications2010

Repressive BMP2 gene regulatory elements near the BMP2 promoter.

Shan Jiang, Ronald L Chandler, David T Fritz, Douglas P Mortlock, Melissa B Rogers

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical and biophysical research communications, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. An autonomous BMP2 regulatory element in mesenchymal cells.Journal of cellular biochemistry · 2011
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Shan JiangDepartment of Biochemistry and Molecular Biology, University of Medicine and Dentistry (UMDNJ), New Jersey Medical School (NJMS), Newark, NJ 07101-1709, USA.
Ronald L Chandler
David T Fritz
Douglas P Mortlock
Melissa B Rogers
Vanderbilt University · USRutgers New Jersey Medical SchoolRutgers, The State University of New Jersey · US

Funding

Training Program in Stem Cell and Regenerative Developmental BiologyT32HD007502 · NICHD · VANDERBILT UNIVERSITY · PI WRIGHT, CHRISTOPHER V · 1997 to 2022
$5.4M
Gdf6 gene expression and evolution in vertebratesR01HD047880 · NICHD · VANDERBILT UNIVERSITY · PI MORTLOCK, DOUGLAS P · 2005 to 2009
$1.8M
RETINOIC ACID REGULATED GENES AND EMBRYOSR01HD031117 · NICHD · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI ROGERS, MELISSA B · 2000 to 2003
$1.2M
NICHD NIH HHS 5T32HD07502NICHD NIH HHS R01 HD031117NICHD NIH HHS R01 HD047880NICHD NIH HHS R01HD31117NICHD NIH HHS R01HD47880NICHD NIH HHS T32 HD007502
6 · The paper itself

Abstract

The level of bone morphogenetic protein 2 (BMP2) profoundly influences essential cell behaviors such as proliferation, differentiation, apoptosis, and migration. The spatial and temporal pattern of BMP2 synthesis, particular in diverse embryonic cells, is highly varied and dynamic. We have identified GC-rich sequences within the BMP2 promoter region that strongly repress gene expression. These elements block the activity of a highly conserved, osteoblast enhancer in response to FGF2 treatment. Both positive and negative gene regulatory elements control BMP2 synthesis. Detecting and mapping the repressive motifs is essential because they impede the identification of developmentally regulated enhancers necessary for normal BMP2 patterns and concentration.

Indexed as

Gene Expression Regulation, DevelopmentalRegulatory Elements, TranscriptionalAnimalsBase SequenceBone Morphogenetic Protein 2Cell LineConserved SequenceEnhancer Elements, GeneticFibroblast Growth Factor 2GC Rich SequenceGenes, ReporterHeLa CellsHumansMiceMolecular Sequence DataOsteoblastsBMP2 protein, humanBmp2 protein, mouseBone Morphogenetic Protein 2Fibroblast Growth Factor 2Repressor Proteins

Identifiers

PMID20060812
PMCPMC2822113
OpenAlexW2024871665

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.