ReviewActa biomaterialia2010
On the biomechanical function of scaffolds for engineering load-bearing soft tissues.
Review in Acta biomaterialia, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Synthetic and Tissue-Engineered Vascular Grafts: Current Status, Emerging Technologies, and Clinical Prospects.Reviews in cardiovascular medicine · 2025Review
- 3D Printing of Chitosan Scaffolds and Films with Varying Roughness for Cultivation of Human Retinal Progenitor Cells.ACS omega · 2025Article
- Recent Advances in 3D Bioprinting of Porous Scaffolds for Tissue Engineering: A Narrative and Critical Review.Journal of functional biomaterials · 2025Review
- Functionalization of Polycaprolactone 3D Scaffolds with Hyaluronic Acid Glycine-Peptide Conjugates and Endothelial Cell Adhesion.Biomacromolecules · 2025Article
- Recent Advances in the Application of Natural and Synthetic Polymer-Based Scaffolds in Musculoskeletal Regeneration.Polymers · 2022Review
- Tannic acid: a crosslinker leading to versatile functional polymeric networks: a review.RSC advances · 2022Review
- Mechanical Considerations of Electrospun Scaffolds for Myocardial Tissue and Regenerative Engineering.Bioengineering (Basel, Switzerland) · 2020Review
- Molecular engineering of metal coordination interactions for strong, tough, and fast-recovery hydrogels.Science advances · 2020Article
- The rationale and emergence of electroconductive biomaterial scaffolds in cardiac tissue engineering.APL bioengineering · 2019Review
- Use of Aligned Microscale Sacrificial Fibers in Creating Biomimetic, Anisotropic Poly(glycerol sebacate) Scaffolds.Polymers · 2019Article
- Polydopamine-based Implantable Multifunctional Nanocarpet for Highly Efficient Photothermal-chemo Therapy.Scientific reports · 2019Article
- Re-designing materials for biomedical applications: from biomimicry to nature-inspired chemical engineering.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2019Review
- Review
- Heart valve scaffold fabrication: Bioinspired control of macro-scale morphology, mechanics and micro-structure.Biomaterials · 2018Article
- Crimped Nanofibrous Biomaterials Mimic Microstructure and Mechanics of Native Tissue and Alter Strain Transfer to Cells.ACS biomaterials science & engineering · 2017Article
- Hydrogels for Biomedical Applications: Cellulose, Chitosan, and Protein/Peptide Derivatives.Gels (Basel, Switzerland) · 2017Review
- Aging of the skeletal muscle extracellular matrix drives a stem cell fibrogenic conversion.Aging cell · 2017Article
- Establishing the Basis for Mechanobiology-Based Physical Therapy Protocols to Potentiate Cellular Healing and Tissue Regeneration.Frontiers in physiology · 2017Review
- Recovery property of double-network hydrogel containing mussel-inspired adhesive moiety and nano-silicate.Journal of materials chemistry. B · 2016Article
- Geometric characterization and simulation of planar layered elastomeric fibrous biomaterials.Acta biomaterialia · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Replacement or regeneration of load-bearing soft tissues has long been the impetus for the development of bioactive materials. While maturing, current efforts continue to be confounded by our lack of understanding of the intricate multi-scale hierarchical arrangements and interactions typically found in native tissues. The current state of the art in biomaterial processing enables a degree of controllable microstructure that can be used for the development of model systems to deduce fundamental biological implications of matrix morphologies on cell function. Furthermore, the development of computational frameworks which allow for the simulation of experimentally derived observations represents a positive departure from what has mostly been an empirically driven field, enabling a deeper understanding of the highly complex biological mechanisms we wish to ultimately emulate. Ongoing research is actively pursuing new materials and processing methods to control material structure down to the micro-scale to sustain or improve cell viability, guide tissue growth, and provide mechanical integrity, all while exhibiting the capacity to degrade in a controlled manner. The purpose of this review is not to focus solely on material processing but to assess the ability of these techniques to produce mechanically sound tissue surrogates, highlight the unique structural characteristics produced in these materials, and discuss how this translates to distinct macroscopic biomechanical behaviors.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.