ArticleDevelopmental biology2010
Regulation of photoreceptor gene expression by the retinal homeobox (Rx) gene product.
Article in Developmental biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Ciliary photoreceptors in sea urchin larvae indicate pan-deuterostome cell type conservation.BMC biology · 2021Article
- The Role of Autophagy in Chemical Proteasome Inhibition Model of Retinal Degeneration.International journal of molecular sciences · 2021Article
- Brain Sensory Organs of the AscidianFrontiers in cell and developmental biology · 2021Review
- Inherited Eye Diseases with Retinal Manifestations through the Eyes of Homeobox Genes.International journal of molecular sciences · 2020Review
- The C-terminus of theMolecular vision · 2019Article
- Identification of retinal homeobox (rax) gene-dependent genes by a microarray approach: The DNA endoglycosylase neil3 is a major downstream component of the rax genetic pathway.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Article
- The role of the Rx homeobox gene in retinal progenitor proliferation and cell fate specification.Mechanisms of development · 2018Article
- Unraveling the genetic cause of a consanguineous family with unilateral coloboma and retinoschisis: expanding the phenotypic variability of RAX mutations.Scientific reports · 2017Article
- Article
- Autoregulation of retinal homeobox (rax) gene promoter activity through a highly conserved genomic element.Genesis (New York, N.Y. : 2000) · 2016Article
- Lxr regulates lipid metabolic and visual perception pathways during zebrafish development.Molecular and cellular endocrinology · 2016Article
- Regulation of photoreceptor gene transcription via a highly conserved transcriptional regulatory element byMolecular vision · 2016Article
- Rax Homeoprotein Regulates Photoreceptor Cell Maturation and Survival in Association with Crx in the Postnatal Mouse Retina.Molecular and cellular biology · 2015Article
- Cooperative activation of Xenopus rhodopsin transcription by paired-like transcription factors.BMC molecular biology · 2014Article
- The Hippo pathway controls a switch between retinal progenitor cell proliferation and photoreceptor cell differentiation in zebrafish.PloS one · 2014Article
- Homeobox genes in the rodent pineal gland: roles in development and phenotype maintenance.Neurochemical research · 2013Review
- An essential role for RAX homeoprotein and NOTCH-HES signaling in Otx2 expression in embryonic retinal photoreceptor cell fate determination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Rax : developmental and daily expression patterns in the rat pineal gland and retina.Journal of neurochemistry · 2011Article
- The Retinal Homeobox (Rx) gene is necessary for retinal regeneration.Developmental biology · 2011Article
- Regulation of retinal homeobox gene transcription by cooperative activity among cis-elements.Gene · 2010Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The retinal homeobox (Rx) gene product is essential for eye development. However little is known about its molecular function. It has been demonstrated that Rx binds to photoreceptor conserved element (PCE-1), a highly conserved element found in the promoter region of photoreceptor-specific genes such as rhodopsin and red cone opsin. We verify that Rx is co-expressed with rhodopsin and red cone opsin in maturing photoreceptors and demonstrate that Rx binds to the rhodopsin and red cone opsin promoters in vivo. We also find that Rx can cooperate with the Xenopus analogs of Crx and Nrl, otx5b and XLMaf (respectively), to activate a Xenopus opsin promoter-dependent reporter. Finally, we demonstrate that reduction of Rx expression in tadpoles results in decreases in expression of several PCE-1 containing photoreceptor genes, abnormal photoreceptor morphology, and impaired vision. Our data suggests that Rx, in combination with other transcription factors, is necessary for normal photoreceptor gene expression, maintenance, and function. This establishes a direct role for Rx in regulation of genes expressed in a differentiated cell type.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.