ArticleNeuroscience2010
Hippocampal cells encode places by forming small anatomical clusters.
Article in Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed.
- Regional and interhemispheric differences of neuronal representations in dentate gyrus and CA3 inferred from expression of zif268.Scientific reports · 2023Article
- Specific patterns of neural activity in the hippocampus after massed or distributed spatial training.Scientific reports · 2023Article
- Hippocampal ensemble dynamics and memory performance are modulated by respiration during encoding.Nature communications · 2023Article
- Article
- Altered pattern separation in Goto-Kakizaki rats.Current research in neurobiology · 2023Article
- Functional Neuronal Topography: A Statistical Approach to Micro Mapping Neuronal Location.Frontiers in neural circuits · 2018Article
- Distance-dependent inhibition facilitates focality of gamma oscillations in the dentate gyrus.Nature communications · 2017Article
- Proximodistal segregation of nonspatial information in CA3: preferential recruitment of a proximal CA3-distal CA1 network in nonspatial recognition memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Hippocampal pyramidal cells: the reemergence of cortical lamination.Brain structure & function · 2011Review
- Pavlovian fear conditioning activates a common pattern of neurons in the lateral amygdala of individual brains.PloS one · 2011Article
- Contribution of Egr1/zif268 to Activity-Dependent Arc/Arg3.1 Transcription in the Dentate Gyrus and Area CA1 of the Hippocampus.Frontiers in behavioral neuroscience · 2011Article
- Functional imaging of hippocampal place cells at cellular resolution during virtual navigation.Nature neuroscience · 2010Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The hippocampus has been hypothesized to function as a "spatial" or "cognitive" map, however, the functional cellular organization of the spatial map remains a mystery. The majority of electrophysiological studies, thus far, have supported the view of a random-type organization in the hippocampus. However, using immediate early genes (IEGs) as an indicator of neuronal activity, we recently observed a cluster-type organization of hippocampal principal cells, whereby a small number ( approximately 4) of nearby cells were activated in rats exposed to a restricted part of an environment. To determine the fine structure of these clusters and to provide a 3D image of active hippocampal cells that encode for different parts of an environment, we established a functional mapping of IEGs zif268 and Homer1a, using in situ hybridization and 3D-reconstruction imaging methods. We found that, in rats exposed to the same location twice, there were significantly more double IEG-expressing cells, and the clusters of nearby cells were more "tightly" formed, in comparison to rats exposed to two different locations. We propose that spatial encoding recruits specific cell ensembles in the hippocampus and that with repeated exposure to the same place the ensembles become better organized to more accurately represent the "spatial map."
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.