ArticleExperimental neurology2010
Functional electrical stimulation helps replenish progenitor cells in the injured spinal cord of adult rats.
Article in Experimental neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 72 citations in OpenAlex.
- Exploring synergistic effects: Atorvastatin and electrical stimulation in spinal cord injury therapy.IBRO neuroscience reports · 2025Article
- Article
- Regeneration and Plasticity Induced by Epidural Stimulation in a Rodent Model of Spinal Cord Injury.International journal of molecular sciences · 2024Article
- Combinatorial strategies for cell transplantation in traumatic spinal cord injury.Frontiers in neuroscience · 2024Review
- Electrical stimulation for the treatment of spinal cord injuries: A review of the cellular and molecular mechanisms that drive functional improvements.Frontiers in cellular neuroscience · 2023Review
- Symptomatic and restorative therapies in neuromyelitis optica spectrum disorders.Journal of neurology · 2022Review
- Efficacy of Electrical Stimulation-Augmented Virtual Reality Training in Improving Balance in Individuals with Incomplete Spinal Cord Injury: Study Protocol of a Randomized Controlled Trial.Asian spine journal · 2021Article
- Electrical stimulation of human neural stem cells via conductive polymer nerve guides enhances peripheral nerve recovery.Biomaterials · 2021Article
- Protein and Polysaccharide-Based Electroactive and Conductive Materials for Biomedical Applications.Molecules (Basel, Switzerland) · 2021Review
- Epidural Spinal Cord Stimulation Promotes Motor Functional Recovery by Enhancing Oligodendrocyte Survival and Differentiation and by Protecting Myelin after Spinal Cord Injury in Rats.Neuroscience bulletin · 2020Article
- Electric Stimulation of Neurogenesis Improves Behavioral Recovery After Focal Ischemia in Aged Rats.Frontiers in neuroscience · 2020Article
- White matter and cognition: making the connection.Journal of neurophysiology · 2016Review
- Enhancing Nervous System Recovery through Neurobiologics, Neural Interface Training, and Neurorehabilitation.Frontiers in neuroscience · 2016Review
- Protective Effect of Electroacupuncture on Neural Myelin Sheaths is Mediated via Promotion of Oligodendrocyte Proliferation and Inhibition of Oligodendrocyte Death After Compressed Spinal Cord Injury.Molecular neurobiology · 2015Article
- Activity-Based Restorative Therapies after Spinal Cord Injury: Inter-institutional conceptions and perceptions.Aging and disease · 2015Review
- Electrical Stimulation Elicits Neural Stem Cells Activation: New Perspectives in CNS Repair.Frontiers in human neuroscience · 2015Review
- Improving the Efficiency of Electrical Stimulation Activities After Spinal Cord Injury.Current physical medicine and rehabilitation reports · 2014Article
- Lower extremity functional electrical stimulation cycling promotes physical and functional recovery in chronic spinal cord injury.The journal of spinal cord medicine · 2013Article
- Engineering therapies in the CNS: what works and what can be translated.Neuroscience letters · 2012Review
- Axon myelination and electrical stimulation in a microfluidic, compartmentalized cell culture platform.Neuromolecular medicine · 2012Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
Functional electrical stimulation (FES) can restore control and offset atrophy to muscles after neurological injury. However, FES has not been considered as a method for enhancing CNS regeneration. This paper demonstrates that FES dramatically enhanced progenitor cell birth in the spinal cord of rats with a chronic spinal cord injury (SCI). A complete SCI at thoracic level 8/9 was performed on 12 rats. Three weeks later, a FES device to stimulate hindlimb movement was implanted into these rats. Twelve identically-injured rats received inactive FES implants. An additional control group of uninjured rats were also examined. Ten days after FES implantation, dividing cells were marked with bromodeoxyuridine (BrdU). The "cell birth" subgroup (half the animals in each group) was sacrificed immediately after completion of BrdU administration, and the "cell survival" subgroup was sacrificed 7 days later. In the injured "cell birth" subgroup, FES induced an 82-86% increase in cell birth in the lumbar spinal cord. In the injured "cell survival" subgroup, the increased lumbar newborn cell counts persisted. FES doubled the proportion of the newly-born cells which expressed nestin and other markers suggestive of tripotential progenitors. In uninjured rats, FES had no effect on cell birth/survival. This report suggests that controlled electrical activation of the CNS may enhance spontaneous regeneration after neurological injuries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.