ArticleDevelopmental biology2010
Regeneration of oral siphon pigment organs in the ascidian Ciona intestinalis.
Article in Developmental biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 50 citations in OpenAlex.
- Integrin-Alpha-6+ Cells Are Responsible for Blastema Formation During Oral Siphon Regeneration in Ciona robusta.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Differentially expressed chaperone genes reveal a stress response required for unidirectional regeneration in the basal chordate Ciona.BMC biology · 2023Article
- The salamander blastema within the broader context of metazoan regeneration.Frontiers in cell and developmental biology · 2023Review
- Article
- Articulating the "stem cell niche" paradigm through the lens of non-model aquatic invertebrates.BMC biology · 2022Review
- Studying Regeneration in Ascidians: An Historical Overview.Methods in molecular biology (Clifton, N.J.) · 2022Review
- Comparative transcriptomic analysis reveals gene regulation mediated by caspase activity in a chordate organism.BMC molecular and cell biology · 2021Article
- Apoptosis is a generator of Wnt-dependent regeneration and homeostatic cell renewal in the ascidian Ciona.Biology open · 2021Article
- And Then There Were Three…: Extreme Regeneration Ability of the Solitary ChordateFrontiers in cell and developmental biology · 2021Article
- Review
- Beyond Adult Stem Cells: Dedifferentiation as a Unifying Mechanism Underlying Regeneration in Invertebrate Deuterostomes.Frontiers in cell and developmental biology · 2020Review
- Progenitor targeting by adult stem cells in Ciona homeostasis, injury, and regeneration.Developmental biology · 2019Article
- Cellular and Molecular Mechanisms of Hydra Regeneration.Results and problems in cell differentiation · 2019Review
- De novo draft assembly of the Botrylloides leachii genome provides further insight into tunicate evolution.Scientific reports · 2018Article
- A microRNA-mRNA expression network during oral siphon regeneration inDevelopment (Cambridge, England) · 2017Article
- The nervous system of the adult ascidian Ciona intestinalis Type A (Ciona robusta): Insights from transgenic animal models.PloS one · 2017Article
- Article
- Evolution of the chordate regeneration blastema: Differential gene expression and conserved role of notch signaling during siphon regeneration in the ascidian Ciona.Developmental biology · 2015Article
- Distal Regeneration Involves the Age Dependent Activity of Branchial Sac Stem Cells in the AscidianRegeneration (Oxford, England) · 2015Article
- Closing the wounds: one hundred and twenty five years of regenerative biology in the ascidian Ciona intestinalis.Genesis (New York, N.Y. : 2000) · 2015Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
Ascidians have powerful capacities for regeneration but the underlying mechanisms are poorly understood. Here we examine oral siphon regeneration in the solitary ascidian Ciona intestinalis. Following amputation, the oral siphon rapidly reforms oral pigment organs (OPO) at its distal margin prior to slower regeneration of proximal siphon parts. The early stages of oral siphon reformation include cell proliferation and re-growth of the siphon nerves, although the neural complex (adult brain and associated organs) is not required for regeneration. Young animals reform OPO more rapidly after amputation than old animals indicating that regeneration is age dependent. UV irradiation, microcautery, and cultured siphon explant experiments indicate that OPOs are replaced as independent units based on local differentiation of progenitor cells within the siphon, rather than by cell migration from a distant source in the body. The typical pattern of eight OPOs and siphon lobes is restored with fidelity after distal amputation of the oral siphon, but as many as 16 OPOs and lobes can be reformed following proximal amputation near the siphon base. Thus, the pattern of OPO regeneration is determined by cues positioned along the proximal distal axis of the oral siphon. A model is presented in which columns of siphon tissue along the proximal-distal axis below pre-existing OPO are responsible for reproducing the normal OPO pattern during regeneration. This study reveals previously unknown principles of oral siphon and OPO regeneration that will be important for developing Ciona as a regeneration model in urochordates, which may be the closest living relatives of vertebrates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.