ArticleDevelopmental cell2009
A Drosophila insulin-like peptide promotes growth during nonfeeding states.
Article in Developmental cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 172 papers.
What it found
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Who cites it
172 citing papers in PubMed, 359 citations in OpenAlex.
- Sex of central neurons controls intestinal niche signalling to drive sex differences in stem cell activity and cancer susceptibility.Nature communications · 2026Article
- Lysine Triggers Acute Oviposition by Activating the 20E-ETH-JH Signaling Cascade inInternational journal of molecular sciences · 2026Article
- Insulin-like peptides play distinct roles in nutrient-dependent plasticity in Drosophila.G3 (Bethesda, Md.) · 2026Article
- Moderate nutritional stress reprogrammes insulin responses to drive enhanced starvation tolerance in Drosophila melanogaster.The Journal of experimental biology · 2026Article
- Insulin-like peptide has antagonistic pleiotropic effects on male combat traits and survival traits in an armed beetle.The Journal of experimental biology · 2026Article
- An insulin-like peptide mediates trehalose storage in the western tarnished plant bug, Lygus hesperus.Journal of insect physiology · 2025Article
- The blood-brain barrier regulates brain tumor growth through the SLC36 amino acid transporter Pathetic in Drosophila.PLoS biology · 2025Article
- Structure and activation of the Drosophila insulin receptor by three Drosophila insulin-like peptides.Nature communications · 2025Article
- The insulin-like peptides Dilp2 and Dilp6 exhibit divergent responses to dietary sugar and protein inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- An ovarian insulin-like peptide specifically regulates energy allocation and oocyte development in nutrition-restricted cockroaches.BMC biology · 2025Article
- 20-Hydroxyecdysone Regulates the Expression of 30 Genes Specifically Expressed in Larval Digestive Tube of the Silkworm,Insects · 2025Article
- Analysis of Transcripts in the Fly Cell Atlas Reveals Additional Cell Populations in themicroPublication biology · 2025Article
- Article
- Synchronizing Drosophila larvae with the salivary gland reporter Sgs3-GFP for discovery of phenotypes in the late third instar stage.Developmental biology · 2024Article
- Compensatory enhancement of input maintains aversive dopaminergic reinforcement in hungry Drosophila.Neuron · 2024Article
- Scaling between cell cycle duration and wing growth is regulated by Fat-Dachsous signaling ineLife · 2024Article
- Scaling between cell cycle duration and wing growth is regulated by Fat-Dachsous signaling inbioRxiv : the preprint server for biology · 2024Article
- JAK/STAT mediated insulin resistance in muscles is essential for effective immune response.Cell communication and signaling : CCS · 2024Article
- Betulinic Acid Increases the Lifespan ofNutrients · 2024Article
- Biochemical characterization of the Drosophila insulin receptor kinase and longevity-associated mutants.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
112 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
In metazoans, tissue growth relies on the availability of nutrients--stored internally or obtained from the environment--and the resulting activation of insulin/IGF signaling (IIS). In Drosophila, growth is mediated by seven Drosophila insulin-like peptides (Dilps), acting through a canonical IIS pathway. During the larval period, animals feed and Dilps produced by the brain couple nutrient uptake with systemic growth. We show here that, during metamorphosis, when feeding stops, a specific DILP (Dilp6) is produced by the fat body and relays the growth signal. Expression of DILP6 during pupal development is controlled by the steroid hormone ecdysone. Remarkably, DILP6 expression is also induced upon starvation, and both its developmental and environmental expression require the Drosophila FoxO transcription factor. This study reveals a specific class of ILPs induced upon metabolic stress that promotes growth in conditions of nutritional deprivation or following developmentally induced cessation of feeding.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.