Evidence map›Paper›PMID 20059645›Full record

ReviewJournal of internal medicine2010

Emerging peptide nanomedicine to regenerate tissues and organs.

M J Webber, J A Kessler, S I Stupp

Abstract readReview
In one paragraph

Review in Journal of internal medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed.

  1. Article
  2. ATP-Regulated Formation of Transient Peptide Amphiphiles Superstructures.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. AnFrontiers in bioengineering and biotechnology · 2020
    Article
  10. Review
  11. Article
  12. Article
  13. Peptide-Based Functional Biomaterials for Soft-Tissue Repair.Frontiers in bioengineering and biotechnology · 2019
    Review
  14. A novel hydrogel scaffold for periodontal ligament stem cells.Interventional medicine & applied science · 2018
    Article
  15. Review
  16. Article
  17. Article
  18. Peptide hormones and lipopeptides: from self-assembly to therapeutic applications.Journal of peptide science : an official publication of the European Peptide Society · 2017
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

M J WebberNorthwestern University Department of Biomedical Engineering, Evanston, IL, USA.
J A Kessler
S I Stupp

Funding

Regenerative Scaffold Technologies for CNS and DiabetesR01EB003806 · NIBIB · NORTHWESTERN UNIVERSITY AT CHICAGO · PI STUPP, SAMUEL I · 2004 to 2015
$10.7M
REGULATION OF NEUROTRANSMITTER METABOLISMR01NS020778 · NINDS · YESHIVA UNIVERSITY · PI KESSLER, JOHN A · 1985 to 2014
$4.6M
MECHANISMS GOVERNING NEURONAL DEVELOPMENTR01NS020013 · NINDS · YESHIVA UNIVERSITY · PI KESSLER, JOHN A · 1985 to 2013
$4.1M
NIBIB NIH HHS R01 EB003806NINDS NIH HHS R01 NS020013NINDS NIH HHS R01 NS020778
6 · The paper itself

Abstract

Peptide nanostructures containing bioactive signals offer exciting novel therapies of broad potential impact in regenerative medicine. These nanostructures can be designed through self-assembly strategies and supramolecular chemistry, and have the potential to combine bioactivity for multiple targets with biocompatibility. It is also possible to multiplex their functions by using them to deliver proteins, nucleic acids, drugs and cells. In this review, we illustrate progress made in this new field by our group and others using peptide-based nanotechnology. Specifically, we highlight the use of self-assembling peptide amphiphiles towards applications in the regeneration of the central nervous system, vasculature and hard tissue along with the transplant of islets and the controlled release of nitric oxide to prevent neointimal hyperplasia. Also, we discuss other self-assembling oligopeptide technology and the progress made with these materials towards the development of potential therapies.

Indexed as

AnimalsBiocompatible MaterialsHumansNanostructuresNanotechnologyPeptidesProtein BindingRegenerative MedicineBiocompatible MaterialsPeptides

Identifiers

PMID20059645
PMCPMC3676424

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.