ArticleHIV medicine2010
Mode of delivery in HIV-infected pregnant women and prevention of mother-to-child transmission: changing practices in Western Europe.
Article in HIV medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01450059 (Maternal-fetal CD4 Microchimerism in HiV Exposed Newborns After Spontaneous Delivery and Cesarean Section), which is not on this map. Cited by 23 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Maternal-fetal CD4 Microchimerism in HiV Exposed Newborns After Spontaneous Delivery and Cesarean Section
Who cites it
23 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Estimating the effect of maternal viral load on perinatal and postnatal HIV transmission: a systematic review and meta-analysis.Lancet (London, England) · 2025Pooled it
- Motherhood and decision-making among women living with HIV in developed countries: a systematic review with qualitative research synthesis.Reproductive health · 2021Pooled it
- Mother-to-child HIV transmission and its correlates in India: systematic review and meta-analysis.BMC pregnancy and childbirth · 2020Pooled it
- Mother-to-child transmission of HIV infection and its associated factors in Ethiopia: a systematic review and meta-analysis.BMC infectious diseases · 2018Pooled it
- Elective cesarean section for women living with HIV: a systematic review of risks and benefits.AIDS (London, England) · 2017Pooled it
- Perinatal HIV in Europe: Clinical Advances and Psychosocial Challenges-A Scoping Review.Tropical medicine and infectious disease · 2026Review
- Pregnancy Management in HIV Viral Controllers: Twenty Years of Experience.Pathogens (Basel, Switzerland) · 2024Article
- Induced abortions of women living with HIV in Finland 1987-2019: a national register study.BMC pregnancy and childbirth · 2023Article
- Prevention of mother-to-child transmission of HIV in Kermanshah, west of Iran from 2014 to 2021.BMC pediatrics · 2023Article
- Testing for HIV Increases the Odds of Correct Fetal Ultrasound Result.Tropical medicine and infectious disease · 2022Article
- Review
- HIV in pregnancy - An update.European journal of obstetrics, gynecology, and reproductive biology · 2021Article
- HIV testing, test results and factors influencing among infants born to HIV positive mothers in public hospitals of Mekelle City, North Ethiopia: a cross-sectional study.BMC infectious diseases · 2020Article
- Vaginal delivery in women with HIV in Italy: results of 5 years of implementation of the national SIGO-HIV protocol.Infection · 2019Article
- Patterns of caesarean section in HIV infected and non-infected women in Malawi: is caesarean section used for PMTCT?BMC pregnancy and childbirth · 2018Article
- Vertical Transmission of HIV-1 in the Metropolitan Area of Belo Horizonte, Brazil: 2006-2014.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2018Observational
- Most women living with HIV can deliver vaginally-National data from Finland 1993-2013.PloS one · 2018Article
- Factors influencing the decision that women make on their mode of delivery: the Health Belief Model.BMC health services research · 2015Article
- Full Viral Suppression, Low-Level Viremia, and Quantifiable Plasma HIV-RNA at the End of Pregnancy in HIV-Infected Women on Antiretroviral Treatment.AIDS research and human retroviruses · 2015Observational
- Complications of cesarean deliveries among HIV-infected women in the United States.AIDS (London, England) · 2014Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectivesThe aim of the study was to examine temporal and geographical patterns of mode of delivery in the European Collaborative Study (ECS), identify factors associated with elective caesarean section (CS) delivery in the highly active antiretroviral therapy (HAART) era and explore associations between mode of delivery and mother-to-child transmission (MTCT).
methodsThe ECS is a cohort study in which HIV-infected pregnant women are enrolled and their infants prospectively followed. Data on 5238 mother-child pairs (MCPs) enrolled in Western European ECS sites between 1985 and 2007 were analysed.
resultsThe elective CS rate increased from 16% in 1985-1993 to 67% in 1999-2001, declining to 51% by 2005-2007. In 2002-2004, 10% of infants were delivered vaginally, increasing to 34% by 2005-2007. During the HAART era, women in Belgium, the United Kingdom and the Netherlands were less likely to deliver by elective CS than those in Italy and Spain [adjusted odds ratio (AOR) 0.07; 95% confidence interval (CI) 0.04-0.12]. The MTCT rate in 2005-2007 was 1%. Among MCPs with maternal HIV RNA<400 HIV-1 RNA copies/mL (n=960), elective CS was associated with 80% decreased MTCT risk (AOR 0.20; 95% CI 0.05-0.65) adjusting for HAART and prematurity. Two infants born to 559 women with viral loads <50 copies/mL were infected, one of whom was delivered by elective CS (MTCT rate 0.4%; 95% CI 0.04-1.29).
conclusionsOur findings suggest that elective CS prevents MTCT even at low maternal viral loads, but the study was insufficiently powered to enable a conclusion to be drawn as to whether this applies for viral loads <50 copies/mL. Diverging mode of delivery patterns in Europe reflect uncertainties regarding the risk-benefit balance of elective CS for women on successful HAART.
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