ArticleAIDS patient care and STDs2010
Antiretroviral prescribing patterns in treatment-naïve patients in the United States.
Article in AIDS patient care and STDs, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Current Antiretroviral Treatment Among People With Human Immunodeficiency Virus in the United States: Findings from the Centers for AIDS Research Network of Integrated Clinic Systems Cohort.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Trends in antiretroviral therapy prescription, durability and modification: new drugs, more changes, but less failure.AIDS (London, England) · 2018Article
- Patient preferences for antiretroviral therapy: effectiveness, quality of life, access and novel delivery methods.Patient preference and adherence · 2017Article
- Brief Report: Factors Associated With the Selection of Initial Antiretroviral Therapy From 2009 to 2012.Journal of acquired immune deficiency syndromes (1999) · 2017Article
- Development of peptide inhibitors of HIV transmission.Bioactive materials · 2016Review
- Unanticipated Effects of New Drug Availability on Antiretroviral Durability: Implications for Comparative Effectiveness Research.Open forum infectious diseases · 2016Article
- Impact of defined clinical population and missing data on temporal trends in HIV viral load estimation within a health care system.HIV medicine · 2015Article
- From pills to patients: an evaluation of data sources to determine the number of people living with HIV who are receiving antiretroviral therapy in Germany.BMC public health · 2015Article
- EFV/FTC/TDF-associated hepatotoxicity: a case report and review.AIDS patient care and STDs · 2013Review
- Mixed-methods evaluation of a telehealth collaborative care program for persons with HIV infection in a rural setting.Journal of general internal medicine · 2013Article
- When to start antiretroviral therapy: as soon as possible.BMC medicine · 2013Review
- Outcomes of second combination antiretroviral therapy regimens among HIV-infected persons in clinical care: a multicenter cohort study.AIDS research and human retroviruses · 2013Article
- Predictive accuracy of the Veterans Aging Cohort Study index for mortality with HIV infection: a North American cross cohort analysis.Journal of acquired immune deficiency syndromes (1999) · 2013Article
- Economic savings versus health losses: the cost-effectiveness of generic antiretroviral therapy in the United States.Annals of internal medicine · 2013Article
- Receipt of opioid analgesics by HIV-infected and uninfected patients.Journal of general internal medicine · 2013Article
- Patient-reported symptoms on the antiretroviral regimen efavirenz/emtricitabine/tenofovir.AIDS patient care and STDs · 2012Article
- Relationship between minority nonnucleoside reverse transcriptase inhibitor resistance mutations, adherence, and the risk of virologic failure.AIDS (London, England) · 2012Review
- Comparative outcomes of tenofovir-based and zidovudine-based antiretroviral therapy regimens in Lusaka, Zambia.Journal of acquired immune deficiency syndromes (1999) · 2011Article
- Immunological profile in persons under antiretroviral therapy in a rural Nigerian hospital.Journal of public health in Africa · 2010Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Numerous antiretroviral therapy (ART) regimens are recommended for first-line and subsequent HIV care, but regimen selection for clinical use may not represent the full range of options. We hypothesized that despite an increase in available antiretrovirals, clinical trial data on regimen efficacy and fixed-dose combination options have lead to uniformity in initial ART. We evaluated regimen selection for ART-naïve patients at the University of Alabama at Birmingham (UAB) 1917 Clinic between January 2000 and December 2007. The annual number of unique initial regimens was quantified. Initial regimen variability was expressed as regimens per 100 patients. Subsequent ART regimens were characterized for complexity via regimen sequence trees detailing the first three generations of regimens for patients starting the two most common initial combinations. Four hundred eighty-two ART-naïve patients were treated with 39 unique initial regimens (8.0 regimens per 100 patients). Variability in initial regimen selection was highest in the first 6 years (14.9-24.4 regimens per 100 patients). A sharp decline was observed in 2006 (16.1 regimens per 100 patients) and 2007 (6.5 regimens per 100 patients). The most dramatic shift in drug selection involved an increase in emtricitabine plus tenofovir plus efavirenz, from 0% in 2003 to 85% in 2007. During the study period, 205 of 482 (43%) patients required a change in initial therapy. Of these, 156 of 205 (76%) had a unique sequence of regimens. A shift toward homogeneity of initial ART was observed (85% of patients received the same first-line regimen in 2007). In contrast, regimen sequencing beyond the first regimen remained complex. These shifts in ART prescribing patterns may have implications for collaborative HIV care.
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