ArticleMolecular and cellular biology1991
Identification of single-stranded-DNA-binding proteins that interact with muscle gene elements.
Article in Molecular and cellular biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 70 citations in OpenAlex.
- The WNT/β-catenin dependent transcription: A tissue-specific business.WIREs mechanisms of disease · 2021Review
- Sequence specificity of single-stranded DNA-binding proteins: a novel DNA microarray approach.Nucleic acids research · 2007Article
- Characterization of the DNA-binding domain of the avian Y-box protein, chkYB-2, and mutational analysis of its single-strand binding motif in the Rous sarcoma virus enhancer.Journal of virology · 1998Article
- In vivo transcriptional regulation of the human immunodeficiency virus in the central nervous system in transgenic mice.Journal of virology · 1996Article
- Single-strand-DNA-binding factors specifically recognize the pyrimidine element in the chick alpha2(I) collagen gene promoter.The Biochemical journal · 1996Article
- A 39-kD DNA-binding protein from mouse brain stimulates transcription of myelin basic protein gene in oligodendrocytic cells.The Journal of cell biology · 1995Article
- Negative regulation of the vascular smooth muscle alpha-actin gene in fibroblasts and myoblasts: disruption of enhancer function by sequence-specific single-stranded-DNA-binding proteins.Molecular and cellular biology · 1995Article
- The embryonic enhancer-binding protein SSAP contains a novel DNA-binding domain which has homology to several RNA-binding proteins.Molecular and cellular biology · 1995Article
- A sequence-specific single-strand DNA binding protein that contacts repressor sequences in the human GM-CSF promoter.Nucleic acids research · 1994Article
- A Chlamydomonas protein that binds single-stranded G-strand telomere DNA.The EMBO journal · 1994Article
- The yeast protein encoded by PUB1 binds T-rich single stranded DNA.Nucleic acids research · 1994Article
- Interaction of two sequence-specific single-stranded DNA-binding proteins with an essential region of the beta-casein gene promoter is regulated by lactogenic hormones.Molecular and cellular biology · 1993Article
- Selective binding of the estrogen receptor to one strand of the estrogen responsive element.Nucleic acids research · 1993Article
- A novel sequence-specific DNA-binding protein, LCP-1, interacts with single-stranded DNA and differentially regulates early gene expression of the human neurotropic JC virus.Journal of virology · 1992Article
- Two cellular single-strand-specific DNA-binding proteins interact with two regions of the bovine papillomavirus type 1 genome, including the origin of DNA replication.Journal of virology · 1992Article
- The yeast alpha 1 and MCM1 proteins bind a single strand of their duplex DNA recognition site.Molecular and cellular biology · 1992Article
- A single-stranded DNA-binding protein from Crithidia fasciculata recognizes the nucleotide sequence at the origin of replication of kinetoplast DNA minicircles.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- The rat poly pyrimidine tract binding protein (PTB) interacts with a single-stranded DNA motif in a liver-specific enhancer.Nucleic acids research · 1992Article
- A CT promoter element binding protein: definition of a double-strand and a novel single-strand DNA binding motif.Nucleic acids research · 1992Article
- Minisatellite binding protein Msbp-1 is a sequence-specific single-stranded DNA-binding protein.Nucleic acids research · 1991Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A sequence-specific DNA-binding protein from skeletal-muscle extracts that binds to probes of three muscle gene DNA elements is identified. This protein, referred to as muscle factor 3, forms the predominant nucleoprotein complex with the MCAT gene sequence motif in an electrophoretic mobility shift assay. This protein also binds to the skeletal actin muscle regulatory element, which contains the conserved CArG motif, and to a creatine kinase enhancer probe, which contains the E-box motif, a MyoD-binding site. Muscle factor 3 has a potent sequence-specific, single-stranded-DNA-binding activity. The specificity of this interaction was demonstrated by sequence-specific competition and by mutations that diminished or eliminated detectable complex formation. MyoD, a myogenic determination factor that is distinct from muscle factor 3, also bound to single-stranded-DNA probes in a sequence-specific manner, but other transcription factors did not. Multiple copies of the MCAT motif activated the expression of a heterologous promoter, and a mutation that eliminated expression was correlated with diminished factor binding. Muscle factor 3 and MyoD may be members of a class of DNA-binding proteins that modulate gene expression by their abilities to recognize DNA with unusual secondary structure in addition to specific sequence.
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