ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2010
Collagen scaffold supplementation does not improve the functional properties of the repaired anterior cruciate ligament.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Nanosurgical and Bioengineering Treatment of Human Anterior Cruciate Ligament Tears with Ultrasound-Guided Injection of Modified Platelet-Rich Plasma Using Human Cell Memory Based on Clinical, Ultrasound, MRI, and Nanoscope Analyses: A Double-Blind Randomized Trial.Journal of clinical medicine · 2024Article
- Fibrin-Based Biomaterial Systems to Enhance Anterior Cruciate Ligament Healing.Medical devices & sensors · 2021Article
- The effect of thermosensitive hydrogel platelet-rich-plasma complex in the treatment of partial tear of anterior cruciate ligament in rat model.Journal of orthopaedic translation · 2020Article
- Bioaugmentation in the surgical treatment of anterior cruciate ligament injuries: A review of current concepts and emerging techniques.SAGE open medicine · 2020Review
- Cartilage Damage Is Related to ACL Stiffness in a Porcine Model of ACL Repair.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019Article
- The non-reconstructive treatment of complete ACL tear with biological enhancement in clinical and preclinical studies: A systematic review.Asia-Pacific journal of sports medicine, arthroscopy, rehabilitation and technology · 2018Review
- Ultrasound-Mediated Gene Delivery Enhances Tendon Allograft Integration in Mini-Pig Ligament Reconstruction.Molecular therapy : the journal of the American Society of Gene Therapy · 2018Article
- Anterior cruciate ligament repair - past, present and future.Journal of experimental orthopaedics · 2018Review
- Biologic Approaches for the Treatment of Partial Tears of the Anterior Cruciate Ligament: A Current Concepts Review.Orthopaedic journal of sports medicine · 2017Article
- Effect of low-temperature ethylene oxide and electron beam sterilization on the in vitro and in vivo function of reconstituted extracellular matrix-derived scaffolds.Journal of biomaterials applications · 2015Article
- Biomechanical Outcomes of Bridge-enhanced Anterior Cruciate Ligament Repair Are Influenced by Sex in a Preclinical Model.Clinical orthopaedics and related research · 2015Article
- Electron beam sterilization does not have a detrimental effect on the ability of extracellular matrix scaffolds to support in vivo ligament healing.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2015Article
- Bio-enhanced repair of the anterior cruciate ligament.Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association · 2015Article
- Addition of autologous mesenchymal stem cells to whole blood for bioenhanced ACL repair has no benefit in the porcine model.The American journal of sports medicine · 2015Article
- A comparison of the fixation strengths provided by different intraosseous tendon lengths during anterior cruciate ligament reconstruction: a biomechanical study in a porcine tibial model.Clinics in orthopedic surgery · 2014Article
- Basic science of anterior cruciate ligament injury and repair.Bone & joint research · 2014Article
- Biology of anterior cruciate ligament injury and repair: Kappa delta ann doner vaughn award paper 2013.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2013Article
- Healing of the goat anterior cruciate ligament after a new suture repair technique and bioscaffold treatment.Tissue engineering. Part A · 2013Article
- Anterior cruciate ligament surgery in the rabbit.Journal of orthopaedic surgery and research · 2013Article
- 2011 AOA Symposium: Tissue Engineering and Tissue Regeneration: AOA critical issues.The Journal of bone and joint surgery. American volume · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Primary suture anterior cruciate ligament (ACL) repair was abandoned in favor of reconstruction due to a high rate of clinical failures. However, the insertion of a collagen scaffold loaded with platelets into the wound at the time of suture repair ("enhanced primary repair") has been shown to improve functional healing in animal models. Our objectives were to determine if using a collagen scaffold alone (without platelets) would be sufficient to increase the structural properties of the repaired ACL and decrease postoperative knee laxity compared to suture repair without the scaffold. Eight Yucatan minipigs underwent bilateral ACL transection and suture repair. In one knee, the repair was augmented with a collagen scaffold (SCAFFOLD group) while the other had suture alone (SUTURE group). After 13 weeks of healing, knee joint laxity and the structural properties of the ACL were measured. The addition of the collagen scaffold to suture repair of a transected ACL did not significantly improve the mean anteroposterior knee laxity [SCAFFOLD vs. SUTURE: 6.1 +/- 1.4 vs. 4.4 +/- 2.0 mm (p = 0.07), 8.1 +/- 2.0 vs. 7.6 +/- 2.0 mm (p = 0.66), and 6.2 +/- 1.2 vs. 6.1 +/- 1.8 mm (p = 0.85) at 30 degrees, 60 degrees, and 90 degrees flexion, respectively]. Likewise, there were no significant differences in the structural properties [SCAFFOLD vs. SUTURE: 367 +/- 185.9 vs. 322 +/- 122.0N (p = 0.66) and 90.7 +/- 29.5 vs. 85.0 +/- 30.3N/mm (p = 0.74) for the yield load and linear stiffness, respectively]. The use of a collagen scaffold alone to enhance suture repair of the ACL was ineffective in this animal model. Future work will be directed at stimulating biological activity in the scaffold.
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