ReviewIUBMB life2010
Agonist-selective signaling of G protein-coupled receptor: mechanisms and implications.
Review in IUBMB life, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed.
- Structural Modification and Development ofJournal of medicinal chemistry · 2026Article
- The Buprenorphine Paradox: How Buprenorphine Triggers and Resolves Opioid Withdrawal.Addiction biology · 2026Article
- Assessment of the potential of novel and classical opioids to induce respiratory depression in mice.British journal of pharmacology · 2023Article
- GMolecular pharmacology · 2023Article
- The therapeutic potential of ultra-short-acting β-receptor antagonists in perioperative analgesic: Evidence from preclinical and clinical studies.Frontiers in pharmacology · 2022Review
- G-Protein Coupled Receptor Targeting on Myeloid Cells in Atherosclerosis.Frontiers in pharmacology · 2019Review
- Potentiation of Morphine-Induced Antinociception by Propranolol: The Involvement of Dopamine and GABA Systems.Frontiers in pharmacology · 2017Article
- In Silico Modeling of Novel Drug Ligands for Treatment of Concussion Associated Tauopathy.Journal of cellular biochemistry · 2016Article
- Opioid doses required for pain management in lung cancer patients with different cholesterol levels: negative correlation between opioid doses and cholesterol levels.Lipids in health and disease · 2016Article
- Wheel running reduces high-fat diet intake, preference and mu-opioid agonist stimulated intake.Behavioural brain research · 2015Article
- Targeting G protein coupled receptor-related pathways as emerging molecular therapies.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2015Review
- Cellular signalling of non-synonymous single-nucleotide polymorphisms of the human μ-opioid receptor (OPRM1).British journal of pharmacology · 2015Review
- Development and evaluation of small peptidomimetic ligands to protease-activated receptor-2 (PAR2) through the use of lipid tethering.PloS one · 2014Article
- Endocytic profiles of δ-opioid receptor ligands determine the duration of rapid but not sustained cAMP responses.Molecular pharmacology · 2014Article
- 3-(1H-indol-3-yl)-2-[3-(4-nitrophenyl)ureido]propanamide enantiomers with human formyl-peptide receptor agonist activity: molecular modeling of chiral recognition by FPR2.Biochemical pharmacology · 2013Article
- Posttranslation modification of G protein-coupled receptor in relationship to biased agonism.Methods in enzymology · 2013Article
- Hyaluronic acid induces activation of the κ-opioid receptor.PloS one · 2013Article
- Lanthanide labeling of a potent protease activated receptor-2 agonist for time-resolved fluorescence analysis.Bioconjugate chemistry · 2012Article
- δ-Opioid mechanisms for ADL5747 and ADL5859 effects in mice: analgesia, locomotion, and receptor internalization.The Journal of pharmacology and experimental therapeutics · 2012Article
- Epigenetics of µ-opioid receptors: intersection with HIV-1 infection of the central nervous system.Journal of cellular physiology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Agonist-selective signaling or ligand-biased signaling of G protein-coupled receptor (GPCR) has become the focus of an increasing number of laboratories. The principle of this concept is that agonist possesses different abilities to activate different signaling pathways. Current review summarizes the observations of agonist-selective signaling of various GPCRs, indicating the significance of agonist-selective signaling in biological processes. In addition, current review also provides an overview on how agonist-selective signaling is initiated. Especially, the relationship between GPCR-G protein interaction and GPCR-beta-arrestin interaction is discussed in depth.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.