ArticleThe Journal of comparative neurology2010
Dopamine receptors in a songbird brain.
Article in The Journal of comparative neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
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Who cites it
85 citing papers in PubMed, 145 citations in OpenAlex.
- Dopamine D1Aa and D2a Receptor Expression in the Auditory System of a Vocal Fish.The Journal of comparative neurology · 2026Article
- Dopaminergic Innervation of the Nidopallium Caudolaterale in the Japanese Quail.The Journal of comparative neurology · 2026Article
- Insights into Convergent Evolution From Studying Amino Acid Patterns in Independent Lineages of Birds.Genome biology and evolution · 2025Article
- Dopamine D1Aa and D2a Receptor Expression in the Auditory System of a Vocal Fish.bioRxiv : the preprint server for biology · 2025Article
- The songbird basal ganglia connectome.bioRxiv : the preprint server for biology · 2025Article
- Change of Spiny Neuron Structure in the Basal Ganglia Song Circuit and Its Regulation by miR-9 during Song Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Neural mechanism of dopamine modulating singing related behavior in songbirds: an updated review.PeerJ · 2025Review
- Integrative neural mechanisms for social communication of learned vocal behavior.Frontiers in integrative neuroscience · 2025Review
- Molecular characterization of chicken DA systems reveals that the avian personality gene,Frontiers in neuroanatomy · 2025Article
- Neurochemical Characterization of Dopaminoceptive Cells in Song Control Nuclei of Canaries and Their Activation During Song Production: A Multiplex Fluorescent In Situ Hybridization Study.The Journal of comparative neurology · 2024Article
- Consensus Paper: Cerebellum and Reward.Cerebellum (London, England) · 2024Review
- Neurochemistry and circuit organization of the lateral spiriform nucleus of birds: A uniquely nonmammalian direct pathway component of the basal ganglia.The Journal of comparative neurology · 2024Article
- Cell type specializations of the vocal-motor cortex in songbirds.Cell reports · 2023Article
- Context-dependent activation of a social behavior brain network during learned vocal production.Brain structure & function · 2023Article
- A neural hub for holistic courtship displays.Current biology : CB · 2023Article
- Effects of Cortical FoxP1 Knockdowns on Learned Song Preference in Female Zebra Finches.eNeuro · 2023Article
- Context-dependent activation of a social behavior brain network associates with learned vocal production.Research square · 2023Article
- DARPP-32 distinguishes a subset of adult-born neurons in zebra finch HVC.The Journal of comparative neurology · 2022Article
- Contribution of Endocannabinoids to Intrinsic Motivation for Undirected Singing in Adult Zebra Finches.Frontiers in physiology · 2022Article
25 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 3 countries.
Funding
Abstract
Dopamine is a key neuromodulatory transmitter in the brain. It acts through dopamine receptors to affect changes in neural activity, gene expression, and behavior. In songbirds, dopamine is released into the striatal song nucleus Area X, and the levels depend on social contexts of undirected and directed singing. This differential release is associated with differential expression of activity-dependent genes, such as egr1 (avian zenk), which in mammalian brain are modulated by dopamine receptors. Here we cloned from zebra finch brain cDNAs of all avian dopamine receptors: the D1 (D1A, D1B, D1D) and D2 (D2, D3, D4) families. Comparative sequence analyses of predicted proteins revealed expected phylogenetic relationships, in which the D1 family exists as single exon and the D2 family exists as spliced exon genes. In both zebra finch and chicken, the D1A, D1B, and D2 receptors were highly expressed in the striatum, the D1D and D3 throughout the pallium and within the mesopallium, respectively, and the D4 mainly in the cerebellum. Furthermore, within the zebra finch, all receptors, except for D4, showed differential expression in song nuclei relative to the surrounding regions and developmentally regulated expression that decreased for most receptors during the sensory acquisition and sensorimotor phases of song learning. Within Area X, half of the cells expressed both D1A and D2 receptors, and a higher proportion of the D1A-only-containing neurons expressed egr1 during undirected but not during directed singing. Our findings are consistent with hypotheses that dopamine receptors may be involved in song development and social context-dependent behaviors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.