ArticleMolecular and cellular biochemistry2010
Persistent facial pain increases superoxide anion production in the spinal trigeminal nucleus.
Article in Molecular and cellular biochemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- α-Lipoic acid and superoxide dismutase in the management of chronic neck pain: a prospective randomized study.Drugs in R&D · 2014Trial
- Resveratrol: Harnessing Nature's Potential for Chronic Pain Relief.Aging and disease · 2025Review
- Mechanisms for Orofacial Pain: Roles of Immunomodulation, Metabolic Reprogramming, Oxidative Stress and Epigenetic Regulation.Biomedicines · 2025Review
- Involvement of Oxidative Stress and Nutrition in the Anatomy of Orofacial Pain.International journal of molecular sciences · 2023Review
- Mechanisms of action of radon therapy on cytokine levels in normal mice and rheumatoid arthritis mouse model.Journal of clinical biochemistry and nutrition · 2022Article
- Antinociceptive and Anti-Inflammatory Effects of Recombinant Crotamine in Mouse Models of Pain.Toxins · 2021Article
- Vitamin C Acutely Affects Brain Perfusion and Mastication-Induced Perfusion Asymmetry in the Principal Trigeminal Nucleus.Frontiers in systems neuroscience · 2021Article
- Antiallodynic and anti-inflammatory effects of intrathecal R-PIA in a rat model of vincristine-induced peripheral neuropathy.Korean journal of anesthesiology · 2020Article
- Mozart's or Ambient Music do not Affect Autoalgometric Pain Threshold.Translational medicine @ UniSa · 2020Article
- Combination Drug Therapy of Pioglitazone and D-cycloserine Attenuates Chronic Orofacial Neuropathic Pain and Anxiety by Improving Mitochondrial Function Following Trigeminal Nerve Injury.The Clinical journal of pain · 2018Article
- Reduced GABAA receptor α6 expression in the trigeminal ganglion enhanced myofascial nociceptive response.Neuroscience · 2013Article
- Study of antioxidative effects and anti-inflammatory effects in mice due to low-dose X-irradiation or radon inhalation.Journal of radiation research · 2013Review
- Antinociceptive effects of radon inhalation on formalin-induced inflammatory pain in mice.Inflammation · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have demonstrated that there is an increase in oxidative stress in the cerebral cortex of rats after repeated painful stimulation and that long-lasting pain increases the production of superoxide ion (O(2) (-)), nitric oxide and peroxynitrite due to the activation of AMPA and NMDA receptors. The purpose of the present study was to evaluate the possible role of O(2) (-) in the transmission of oro-facial pain. Formaldehyde 1% was injected subcutaneously into one vibrissal pad of adult male Sprague-Dawley rats as a model of persistent pain, then O(2) (-) production and superoxide dismutase (SOD) activity were evaluated in the left and right spinal trigeminal nuclei. O(2) (-) production was revealed using dihidroetidium (DHE) injected at 10 or 45 min after the formalin injection in conscious or anaesthetized rats. A histochemical assay for SOD was performed to evaluate the activity of SOD at 10 min after the formalin injection. The results showed a significant increase in O(2) (-) production in the homolateral nucleus at 45 min. However, there was no significant difference between the two sides at 10 min after the formalin injection. No significant difference was observed in SOD activity between the two sides of the spinal trigeminal nucleus. This study demonstrated that there is an increased production of O(2) (-) in the second phase but not in the first phase of the formalin test; thus O(2) (-) is involved in pain induced by inflammation, but not in acute pain.
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