ArticleCancer research and treatment2009
No association of vascular endothelial growth factor-A (VEGF-A) and VEGF-C expression with survival in patients with gastric cancer.
Article in Cancer research and treatment, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 4 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- VEGF-C expression is associated with the poor survival in gastric cancer tissue.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Prognostic value of vascular endothelial growth factor A expression in gastric cancer: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Prognostic significance of vascular endothelial growth factor immunohistochemical expression in gastric cancer: a meta-analysis.Molecular biology reports · 2012Pooled it
- Prognostic significance of vascular endothelial growth factor expression in gastric carcinoma: a meta-analysis.Journal of cancer research and clinical oncology · 2011Pooled it
- VEGF-C and Lymphatic Vessel Density in Tumor Tissue of Gastric Cancer: Correlations with Pathoclinical Features and Prognosis.Cancers · 2025Article
- Proposed Molecular and miRNA Classification of Gastric Cancer.International journal of molecular sciences · 2018Review
- Optimal management of resected gastric cancer.Cancer management and research · 2018Review
- Correlations between VEGF-A expression and prognosis in patients with gastric adenocarcinoma.International journal of clinical and experimental pathology · 2017Article
- Biomarker analyses in REGARD gastric/GEJ carcinoma patients treated with VEGFR2-targeted antibody ramucirumab.British journal of cancer · 2016Article
- Fentanyl inhibits the progression of human gastric carcinoma MGC-803 cells by modulating NF-κB-dependent gene expressionOncology letters · 2016Article
- Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy.Oncotarget · 2015Review
- The different role of intratumoral and peritumoral lymphangiogenesis in gastric cancer progression and prognosis.BMC cancer · 2015Article
- Overexpression of both VEGF-A and VEGF-C in gastric cancer correlates with prognosis, and silencing of both is effective to inhibit cancer growth.International journal of clinical and experimental pathology · 2013Article
- Molecular mechanisms of lymphatic metastasis in solid tumors of the gastrointestinal tract.International journal of clinical and experimental pathology · 2012Review
- Role of endoglin and VEGF family expression in colorectal cancer prognosis and anti-angiogenic therapies.World journal of clinical oncology · 2011Article
- Cancer-associated fibroblasts are positively correlated with metastatic potential of human gastric cancers.Journal of experimental & clinical cancer research : CR · 2010Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAlthough the vascular endothelial growth factor (VEGF) superfamily has been identified to critically influence tumor-related angiogenesis, the prognostic significance of a VEGF expression in gastric cancer is still controversial. Accordingly, the present study analyzed the VEGF-A and VEGF-C expressions and their impact on the prognosis of patients with gastric cancer. MATERIALS AND
methodsThree hundred seventy-five consecutive patients who underwent surgical resection for gastric adenocarcinoma with a curative intent were enrolled in the present study. Immunohistochemical staining for VEGF-A and VEGF-C was performed using the formalin fixed, paraffin embedded tumor tissues.
resultsPositive VEGF-A and VEGF-C expressions were observed in 337 (90.1%) and 278 (74.9%) cases, respectively. The survival analysis showed that the expression of VEGF-A and VEGF-C had no effect on the OS and DFS. On the multivariate analysis that included age, gender and the TNM stage, no significant association between the grade of the VEGF-A or VEGF-C expression and survival was observed.
conclusionThe current study suggests that the tissue expression of VEGF-A or VEGF-C alone is not an independent prognostic marker for patients with surgically resected gastric adenocarcinoma.
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