ArticleHFSP journal2009
Cellular interfacial and surface tensions determined from aggregate compression tests using a finite element model.
Article in HFSP journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Cell spheroid micromechanics under large deformations.Scientific reports · 2025Article
- Cartilaginous microtissues exhibit extreme resilience under compression with size-dependent mechanical properties.Biomaterials · 2025Article
- Article
- Using Biosensors to Study Organoids, Spheroids and Organs-on-a-Chip: A Mechanobiology Perspective.Biosensors · 2023Review
- Article
- Mechanical properties of cell sheets and spheroids: the link between single cells and complex tissues.Biophysical reviews · 2021Review
- Mechanics of Fluid-Filled Interstitial Gaps. I. Modeling Gaps in a Compact Tissue.Biophysical journal · 2017Article
- Mechanics of Fluid-Filled Interstitial Gaps. II. Gap Characteristics in Xenopus Embryonic Ectoderm.Biophysical journal · 2017Article
- Three-dimensional vertex model for simulating multicellular morphogenesis.Biophysics and physicobiology · 2015Review
- Vertex models of epithelial morphogenesis.Biophysical journal · 2014Review
- Ephrin-Eph signaling in embryonic tissue separation.Cell adhesion & migration · 2014Review
- Glassy dynamics in three-dimensional embryonic tissues.Journal of the Royal Society, Interface · 2013Article
- Three functions of cadherins in cell adhesion.Current biology : CB · 2013Review
- Article
- The role of adhesion energy in controlling cell-cell contacts.Current opinion in cell biology · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although previous studies suggested that the interfacial tension gamma(cc) acting along cell-cell boundaries and the effective viscosity mu of the cell cytoplasm could be measured by compressing a spherical aggregate of cells between parallel plates, the mechanical understanding necessary to extract this information from these tests-tests that have provided the surface tension sigma(cm) acting along cell-medium interfaces-has been lacking. These tensions can produce net forces at the subcellular level and give rise to cell motions and tissue reorganization, the rates of which are regulated by mu. Here, a three-dimensional (3D) cell-based finite element model provides insight into the mechanics of the compression test, where these same forces are at work, and leads to quantitative relationships from which the effective viscosity mu of the cell cytoplasm, the tension gamma(cc) that acts along internal cell-cell interfaces and the surface tension sigma(cp) along the cell-platen boundaries can be determined from force-time curves and aggregate profiles. Tests on 5-day embryonic chick mesencephalon, neural retina, liver, and heart aggregates show that all of these properties vary significantly with cell type, except gamma(cc), which is remarkably constant. These properties are crucial for understanding cell rearrangement and tissue self-organization in contexts that include embryogenesis, cancer metastases, and tissue engineering.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.