ArticleFrontiers in cellular neuroscience2009
Determining k channel activation curves from k channel currents often requires the goldman-hodgkin-katz equation.
Article in Frontiers in cellular neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 35 citations in OpenAlex.
- Article
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- Development and prenatal exposure to androgens alter potassium currents in gonadotropin-releasing hormone neurons from female mice.Journal of neuroendocrinology · 2024Article
- Reply to Kotler et al.: Changing ion concentrations in conductance-based models.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Estradiol Enhances the Depolarizing Response to GABA and AMPA Synaptic Conductances in Arcuate Kisspeptin Neurons by Diminishing Voltage-Gated Potassium Currents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Another interpretation of the Goldman-Hodgkin-Katz equation based on Ling's adsorption theory.European biophysics journal : EBJ · 2018Article
- Novel description of ionic currents recorded with the action potential clamp technique: application to excitatory currents in suprachiasmatic nucleus neurons.Journal of neurophysiology · 2015Article
- Non-linear leak currents affect mammalian neuron physiology.Frontiers in cellular neuroscience · 2015Article
- A Novel Method for the Description of Voltage-Gated Ionic Currents Based on Action Potential Clamp Results-Application to Hippocampal Mossy Fiber Boutons.Frontiers in cellular neuroscience · 2015Article
- A novel analysis of excitatory currents during an action potential from suprachiasmatic nucleus neurons.Journal of neurophysiology · 2013Article
- Efficient calculation of the quasi-static electrical potential on a tetrahedral mesh and its implementation in STEPS.Frontiers in computational neuroscience · 2013Article
- Tuning of EAG K(+) channel inactivation: molecular determinants of amplification by mutations and a small molecule.The Journal of general physiology · 2012Article
- The layer-oriented approach to declarative languages for biological modeling.PLoS computational biology · 2012Article
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- Going native: voltage-gated potassium channels controlling neuronal excitability.The Journal of physiology · 2010Review
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Abstract
Potassium ion current in nerve membrane, I(K), has traditionally been described by I(K) = g(K)(V - E(K)), where g(K) is the K ion conductance, V is membrane potential and E(K) is the K(+) Nernst potential. This description has been unchallenged by most investigators in neuroscience since its introduction almost 60 years ago. The problem with the I(K) approximately (V - E(K)) proportionality is that it is inconsistent with the unequal distribution of K ions in the intra- and extracellular bathing media. Under physiological conditions the intracellular K(+) concentration is significantly higher than the extracellular concentration. Consequently, the slope conductance at potentials positive to E(K) cannot be the same as that for potentials negative to E(K), as the linear proportionality between I(K) and (V - E(K)) requires. Instead I(K) has a non-linear dependence on (V - E(K)) which is well described by the Goldman-Hodgkin-Katz equation. The implications of this result for K(+) channel gating and membrane excitability are reviewed in this report.
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