ArticleCell death and differentiation2010
BUB3 that dissociates from BUB1 activates caspase-independent mitotic death (CIMD).
Article in Cell death and differentiation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 28 citations in OpenAlex.
- TSG101 depletion dysregulates mitochondria and PML NBs, triggering MAD2-overexpressing interphase cell death (MOID) through AIFM1-PML-DAXX pathway.Cell death & disease · 2024Article
- SETD1A function in leukemia is mediated through interaction with mitotic regulators BuGZ/BUB3.EMBO reports · 2023Article
- EWSR1 maintains centromere identity.Cell reports · 2023Article
- CENP-A Ubiquitylation Is Indispensable to Cell Viability.Developmental cell · 2019Article
- SGT1-HSP90 complex is required for CENP-A deposition at centromeres.Cell cycle (Georgetown, Tex.) · 2017Article
- Immunofluorescence Analysis of Endogenous and Exogenous Centromere-kinetochore Proteins.Journal of visualized experiments : JoVE · 2016Article
- PLK2 phosphorylates and inhibits enriched TAp73 in human osteosarcoma cells.Cancer medicine · 2016Article
- The oncogenic role of the cochaperone Sgt1.Oncogenesis · 2015Article
- A motif from Lys216 to Lys222 in human BUB3 protein is a nuclear localization signal and critical for BUB3 function in mitotic checkpoint.The Journal of biological chemistry · 2015Article
- CENP-A K124 Ubiquitylation Is Required for CENP-A Deposition at the Centromere.Developmental cell · 2015Article
- Polo-like kinase 2 acting as a promoter in human tumor cells with an abundance of TAp73.OncoTargets and therapy · 2015Article
- Proteomic profile of pre - B2 lymphoblasts from children with acute lymphoblastic leukemia (ALL) in relation with the translocation (12; 21).Clinical proteomics · 2014Article
- 2n or not 2n: Aneuploidy, polyploidy and chromosomal instability in primary and tumor cells.Seminars in cell & developmental biology · 2013Article
- Tissue-specific expression of p73 C-terminal isoforms in mice.Cell cycle (Georgetown, Tex.) · 2012Article
- Article
- Mitotic Kinases and p53 Signaling.Biochemistry research international · 2012Article
- p53: guardian of ploidy.Molecular oncology · 2011Review
- MTBP plays a crucial role in mitotic progression and chromosome segregation.Cell death and differentiation · 2011Article
- Diverse system stresses: common mechanisms of chromosome fragmentation.Cell death & disease · 2011Article
- p73 in Cancer.Genes & cancer · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The cell death mechanism that prevents aneuploidy caused by a failure of the spindle checkpoint has recently emerged as an important regulatory paradigm. We previously identified a new type of mitotic cell death, termed caspase-independent mitotic death (CIMD), which is induced during early mitosis by partial BUB1 (a spindle checkpoint protein) depletion and defects in kinetochore-microtubule attachment. In this study, we have shown that survived cells that escape CIMD have abnormal nuclei, and we have determined the molecular mechanism by which BUB1 depletion activates CIMD. The BUB3 protein (a BUB1 interactor and a spindle checkpoint protein) interacts with p73 (a homolog of p53), specifically in cells wherein CIMD occurs. The BUB3 protein that is freed from BUB1 associates with p73 on which Y99 is phosphorylated by c-Abl tyrosine kinase, resulting in the activation of CIMD. These results strongly support the hypothesis that CIMD is the cell death mechanism protecting cells from aneuploidy by inducing the death of cells prone to substantial chromosome missegregation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.