ArticleThe EMBO journal2010
Positional dependence of transcriptional inhibition by DNA torsional stress in yeast chromosomes.
Article in The EMBO journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 55 citations in OpenAlex.
- Topoisomerase-mediated resolution of negative DNA supercoiling sustains human transcription and gene activation.bioRxiv : the preprint server for biology · 2026Article
- Topoisomerases regulate alternative transcription start site selection in yeast.G3 (Bethesda, Md.) · 2026Article
- The SMC5/SMC6 complex is critical for resolving R-loop-induced transcription-replication conflicts.Nucleic acids research · 2026Article
- An extrinsic motor directs chromatin loop formation by cohesin.The EMBO journal · 2024Article
- RNA interacts with topoisomerase I to adjust DNA topology.Molecular cell · 2024Article
- Exploring Genetic Interactions with Telomere Protection GeneBiomolecules · 2023Review
- Cohesin Causes Replicative DNA Damage by Trapping DNA Topological Stress.Molecular cell · 2020Article
- The many lives of type IA topoisomerases.The Journal of biological chemistry · 2020Review
- Topoisomerase activity is linked to altered nucleosome positioning and transcriptional regulation in the fission yeast fbp1 gene.PloS one · 2020Article
- Transcriptional supercoiling boosts topoisomerase II-mediated knotting of intracellular DNA.Nucleic acids research · 2019Article
- Eukaryotic core promoters and the functional basis of transcription initiation.Nature reviews. Molecular cell biology · 2018Review
- DNA Supercoiling, Topoisomerases, and Cohesin: Partners in Regulating Chromatin Architecture?International journal of molecular sciences · 2018Review
- Structure and Chromosomal Organization of Yeast Genes Regulated by Topoisomerase II.International journal of molecular sciences · 2018Review
- The Use of Psoralen Photobinding to Study Transcription-Induced Supercoiling.Methods in molecular biology (Clifton, N.J.) · 2018Article
- Observation of DNA intertwining along authentic budding yeast chromosomes.Genes & development · 2017Article
- DNA topology in chromatin is defined by nucleosome spacing.Science advances · 2017Article
- Genome urbanization: clusters of topologically co-regulated genes delineate functional compartments in the genome of Saccharomyces cerevisiae.Nucleic acids research · 2017Article
- Topoisomerases and the regulation of neural function.Nature reviews. Neuroscience · 2016Review
- Article
- DNA Topoisomerases Are Required for Preinitiation Complex Assembly during GAL Gene Activation.PloS one · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
How DNA helical tension is constrained along the linear chromosomes of eukaryotic cells is poorly understood. In this study, we induced the accumulation of DNA (+) helical tension in Saccharomyces cerevisiae cells and examined how DNA transcription was affected along yeast chromosomes. The results revealed that, whereas the overwinding of DNA produced a general impairment of transcription initiation, genes situated at <100 kb from the chromosomal ends gradually escaped from the transcription stall. This novel positional effect seemed to be a simple function of the gene distance to the telomere: It occurred evenly in all 32 chromosome extremities and was independent of the atypical structure and transcription activity of subtelomeric chromatin. These results suggest that DNA helical tension dissipates at chromosomal ends and, therefore, provides a functional indication that yeast chromosome extremities are topologically open. The gradual escape from the transcription stall along the chromosomal flanks also indicates that friction restrictions to DNA twist diffusion, rather than tight topological boundaries, might suffice to confine DNA helical tension along eukaryotic chromatin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.