ReviewCirculation research2010
The impact of macrophage insulin resistance on advanced atherosclerotic plaque progression.
Review in Circulation research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed, 1 synthesis or guideline pooled it, 121 citations in OpenAlex.
- Association of triglyceride-glucose index and its related parameters with the risk of stroke: a meta-analysis.BMC neurology · 2025Pooled it
- Association between circulating endothelial cells and carotid atherosclerosis in patients receiving maintenance hemodialysis.BioMed research international · 2014Trial
- The changing epidemiology of human type 2 diabetes-associated atherosclerosis: Pathophysiological mechanisms and emerging treatment possibilities.Journal of internal medicine · 2026Review
- Link between C-reactive protein-triglyceride glucose index and cardiovascular disease risk in diverse glycemic statuses: a nationwide prospective cohort study.BMC cardiovascular disorders · 2026Article
- Association of C-reactive protein-triglyceride glucose index and its modified indices with stroke risk in individuals at cardiovascular-kidney-metabolic syndrome stages 0-3: a population-based cohort study.Cardiovascular diabetology · 2026Article
- Comparative performance of insulin resistance-related indices in predicting adverse cardiovascular events among individuals with NAFLD and MASLD: a multi-center cohort study.Cardiovascular diabetology · 2026Observational
- Association between the combined c-reactive protein-triglyceride glucose index and hypertension with long-term stroke among cardiovascular-kidney-metabolic syndrome stages 0-3 population: a nationwide prospective cohort study.Cardiovascular diabetology · 2026Article
- C-Reactive Protein-Albumin-Lymphocyte Index as a Predictor of All-Cause and Cardiovascular Mortality in Individuals With Diabetes or Prediabetes: A National Population-Based Cohort Study.International journal of endocrinology · 2026Article
- Longitudinal correlation between cumulative remnant cholesterol inflammatory index and incident diabetes.Diabetology & metabolic syndrome · 2025Article
- Association between metabolic score for insulin resistance and future stroke risk in patients with cardiovascular-kidney-metabolic syndrome stages 0-3: a longitudinal analysis based on CHARLS.Cardiovascular diabetology · 2025Article
- Atherosclerosis and Insulin Resistance: Is There a Link Between Them?Biomedicines · 2025Review
- Association between C-reactive protein-triglyceride glucose index and stroke risk in different glycemic status: insights from the China Health and Retirement Longitudinal Study (CHARLS).Cardiovascular diabetology · 2025Article
- Identification of critical endoplasmic reticulum stress-related genes in advanced atherosclerotic plaque.Scientific reports · 2025Article
- Unveiling the dual threat: combined elevated triglyceride-glucose index and intracranial arterial stenosis burden for enhanced stroke risk stratification.Frontiers in neurology · 2025Article
- Association between triglyceride glucose-waist height ratio and stroke: a population-based study.Frontiers in endocrinology · 2025Article
- C-reactive protein-triglyceride glucose index predicts stroke incidence in a hypertensive population: a national cohort study.Diabetology & metabolic syndrome · 2024Article
- Molecular Pathways of Vulnerable Carotid Plaques at Risk of Ischemic Stroke: A Narrative Review.International journal of molecular sciences · 2024Review
- Diabetes Mellitus to Accelerated Atherosclerosis: Shared Cellular and Molecular Mechanisms in Glucose and Lipid Metabolism.Journal of cardiovascular translational research · 2024Review
- METS-IR as an important predictor of neurological impairment severity in patients with severe cerebral infarction: a multicenter study based on the Chinese population.Frontiers in neurology · 2024Article
- Insulin sensitization by hepatic FoxO deletion is insufficient to lower atherosclerosis in mice.bioRxiv : the preprint server for biology · 2023Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Atherothrombotic vascular disease is the major cause of death and disability in obese and diabetic subjects with insulin resistance. Although increased systemic risk factors in the setting of insulin resistance contribute to this problem, it is likely exacerbated by direct effects of insulin resistance on the arterial wall cells that participate in atherosclerosis. A critical process in the progression of subclinical atherosclerotic lesions to clinically relevant lesions is necrotic breakdown of plaques. Plaque necrosis, which is particularly prominent in the lesions of diabetics, is caused by the combination of macrophage apoptosis and defective phagocytic clearance, or efferocytosis, of the apoptotic macrophages. One cause of macrophage apoptosis in advanced plaques is activation of a proapoptotic branch of the unfolded protein response, which is an endoplasmic reticulum stress pathway. Macrophages have a functional insulin receptor signaling pathway, and downregulation of this pathway in the setting insulin resistance enhances unfolded protein response-induced apoptosis. Moreover, other aspects of the obesity/insulin-resistance syndrome may adversely affect efferocytosis. These processes may therefore provide an important mechanistic link among insulin resistance, plaque necrosis, and atherothrombotic vascular disease and suggest novel therapeutic approaches to this expanding health problem.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.