ReviewThe Journal of clinical endocrinology and metabolism2010
Update in male osteoporosis.
Review in The Journal of clinical endocrinology and metabolism, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical guidelines for the prevention and treatment of osteoporosis: summary statements and recommendations from the Italian Society for Orthopaedics and Traumatology.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2017Guideline
- Baseline characteristics of participants in the VITamin D and OmegA-3 TriaL (VITAL): Effects on Bone Structure and Architecture.Contemporary clinical trials · 2018Trial
- The local application of a 1% simvastatin gel improves bone regeneration in osteoporotic mandibular defects: a rat model study.Annals of medicine and surgery (2012) · 2025Article
- Article
- Bone health assessment in adults with fragility fracture risk factors between 2002-2014: a retrospective cohort study.BJGP open · 2024Article
- Treatment of osteoporosis using a selective androgen receptor modulator ostarine in an orchiectomized rat model.Endocrine · 2023Article
- Assembling the Puzzle Pieces. Insights for in Vitro Bone Remodeling.Stem cell reviews and reports · 2023Review
- LncRNA PTCSC3 is upregulated in osteoporosis and negatively regulates osteoblast apoptosis.BMC medical genomics · 2022Article
- The pattern and trends of disease burden due to low bone mineral density from 1990 to 2019 in China: findings from the Global Burden of Disease Study 2019.Archives of osteoporosis · 2022Article
- In vivo and in vitro analysis in a rat model using zoledronate and alendronate medication: microbiological and scanning electron microscopy findings on peri-implant rat tissue.BMC oral health · 2021Article
- Molecular Interactions between Dietary Lipids and Bone Tissue during Aging.International journal of molecular sciences · 2021Review
- Delivering fracture prevention services to rural US veterans through telemedicine: a process evaluation.Archives of osteoporosis · 2021Article
- Role of irisin in androgen-deficient muscle wasting and osteopenia in mice.Journal of bone and mineral metabolism · 2020Article
- Isopsoralen ameliorates HExperimental and therapeutic medicine · 2019Article
- Bone alterations in inflammatory bowel diseases.World journal of clinical cases · 2019Review
- Body composition and circulating estradiol are the main bone density predictors in healthy young and middle-aged men.Journal of endocrinological investigation · 2018Article
- An Evidence-Based Review: The Effects of Malaysian Traditional Herbs on Osteoporotic Rat Models.The Malaysian journal of medical sciences : MJMS · 2018Review
- The Effects of Chemical Castration with Degarelix on Bone Turnover: Densitometric and Biomechanics Bone Properties of Male Rats.International journal of endocrinology and metabolism · 2018Article
- Role of Serum Osteoprotegerin as a Diagnostic Indicator of Primary Osteoporosis in Perimenopausal and Postmenopausal Women: An Indian Perspective.Malaysian orthopaedic journal · 2018Article
- Psoralen and Isopsoralen Ameliorate Sex Hormone Deficiency-Induced Osteoporosis in Female and Male Mice.BioMed research international · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
contextOsteoporosis in men is becoming an increasingly important public health problem. One in five men over the age of 50 yr will suffer an osteoporotic fracture during their lifetime, and men who sustain fractures have an increased mortality risk. EVIDENCE ACQUISITION: Evidence was obtained by PubMed search and author's knowledge of the field. EVIDENCE SYNTHESIS: Studies using computed quantitative tomography and high-resolution peripheral computed quantitative tomography have provided new insights into the bone structural changes with aging in men, including the somewhat surprising demonstration of significant, ongoing trabecular bone loss starting in young adult life. In addition, there are now data demonstrating that serum estradiol levels are important predictors of fracture risk in men and that there is a threshold estradiol level below which not only bone loss but also fracture risk increases markedly. Criteria for diagnosing and managing osteoporosis in men are also evolving, including the application of the fracture risk assessment tool to derive 10-yr fracture risks in men. Three bisphosphonates (alendronate, risedronate, and zolendronic acid) and teriparatide are currently U.S. Food and Drug Administration approved for the treatment of osteoporosis in men, with a number of new compounds, including a monoclonal antibody against receptor activator of nuclear factor-kappaB ligand, selective estrogen receptor modulators, and selective androgen receptor modulators in varying stages of development.
conclusionsDespite significant advances, there remain a number of key unresolved issues regarding the pathogenesis and management of male osteoporosis, not the least of which is increasing public awareness of this important cause of morbidity and mortality in men.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.